Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction
ObjectivesMigraine is often combined with vestibular dysfunction, particularly in patients with chronic migraine (CM). However, the pathogenesis of migraine chronification leading to vestibular dysfunction is not fully understood. The current study investigated whether structural or functional impai...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-07-01
|
| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1153641/full |
| _version_ | 1797789235670941696 |
|---|---|
| author | Liang Dong Xiaoping Fan Yulan Fan Ximao Li Hui Li Jiying Zhou |
| author_facet | Liang Dong Xiaoping Fan Yulan Fan Ximao Li Hui Li Jiying Zhou |
| author_sort | Liang Dong |
| collection | DOAJ |
| description | ObjectivesMigraine is often combined with vestibular dysfunction, particularly in patients with chronic migraine (CM). However, the pathogenesis of migraine chronification leading to vestibular dysfunction is not fully understood. The current study investigated whether structural or functional impairments to the brain during migraine chronification could be associated with vestibular dysfunction development.MethodsThe eligible participants underwent clinical assessment and magnetic resonance imaging (MRI) scans. Voxel-based morphometry (VBM) determined structural impairment by evaluating alterations in gray matter volume (GMV). Functional impairment was assessed by the mean amplitude of low-frequency fluctuation (mALFF). Furthermore, the resting-state functional connectivity (rsFC) of regions possessing impairment was examined with a seed-based approach. We also analyzed the correlations between altered neuroimaging features with clinical variables and performed multiple linear regression.ResultsEighteen CM patients, 18 episodic migraine (EM) patients, and 18 healthy controls (HCs) were included in this study. A one-way ANOVA indicated the group differences in mALFF. These were located within right supramarginal gyrus (SMG), left angular gyrus (AG), middle frontal gyrus (MFG), left middle occipital gyrus (MOG), right rolandic operculum (Rol) and left superior parietal gyrus (SPG). During rsFC analysis, the CM group had more enhanced rsFC of left SPG with left MOG than the EM and HC groups. The EM group revealed enhanced rsFC of left SPG with left AG than the CM and HC groups. In multiple linear regression, after controlling for age, body mass index (BMI) and disease duration, the rsFC of left SPG with left MOG (β = 48.896, p = 0.021) was found to predict the total Dizziness Handicap Inventory (DHI) score with an explained variance of 25.1%. Moreover, the rsFC of left SPG with left MOG (β = 1.253, p = 0.003) and right SMG (β = −1.571, p = 0.049) were significant predictors of migraine frequency, accounting for a total explained variance of 73.8%.ConclusionThe functional impairments due to migraine chronification are primarily concentrated in the multisensory integration-related brain regions. Additionally, the rsFC of SPG with MOG can predict the frequency of migraine and the degree of vestibular dysfunction. Therefore, these neuroimaging features could be potential mechanisms and therapeutic targets for developing vestibular dysfunction in migraine. |
| first_indexed | 2024-03-13T01:47:52Z |
| format | Article |
| id | doaj.art-b61653916c094f92ba5ddd1ffcd3f574 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-03-13T01:47:52Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-b61653916c094f92ba5ddd1ffcd3f5742023-07-03T05:21:43ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-07-011610.3389/fnmol.2023.11536411153641Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunctionLiang Dong0Xiaoping Fan1Yulan Fan2Ximao Li3Hui Li4Jiying Zhou5Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Hospice, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Radiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaObjectivesMigraine is often combined with vestibular dysfunction, particularly in patients with chronic migraine (CM). However, the pathogenesis of migraine chronification leading to vestibular dysfunction is not fully understood. The current study investigated whether structural or functional impairments to the brain during migraine chronification could be associated with vestibular dysfunction development.MethodsThe eligible participants underwent clinical assessment and magnetic resonance imaging (MRI) scans. Voxel-based morphometry (VBM) determined structural impairment by evaluating alterations in gray matter volume (GMV). Functional impairment was assessed by the mean amplitude of low-frequency fluctuation (mALFF). Furthermore, the resting-state functional connectivity (rsFC) of regions possessing impairment was examined with a seed-based approach. We also analyzed the correlations between altered neuroimaging features with clinical variables and performed multiple linear regression.ResultsEighteen CM patients, 18 episodic migraine (EM) patients, and 18 healthy controls (HCs) were included in this study. A one-way ANOVA indicated the group differences in mALFF. These were located within right supramarginal gyrus (SMG), left angular gyrus (AG), middle frontal gyrus (MFG), left middle occipital gyrus (MOG), right rolandic operculum (Rol) and left superior parietal gyrus (SPG). During rsFC analysis, the CM group had more enhanced rsFC of left SPG with left MOG than the EM and HC groups. The EM group revealed enhanced rsFC of left SPG with left AG than the CM and HC groups. In multiple linear regression, after controlling for age, body mass index (BMI) and disease duration, the rsFC of left SPG with left MOG (β = 48.896, p = 0.021) was found to predict the total Dizziness Handicap Inventory (DHI) score with an explained variance of 25.1%. Moreover, the rsFC of left SPG with left MOG (β = 1.253, p = 0.003) and right SMG (β = −1.571, p = 0.049) were significant predictors of migraine frequency, accounting for a total explained variance of 73.8%.ConclusionThe functional impairments due to migraine chronification are primarily concentrated in the multisensory integration-related brain regions. Additionally, the rsFC of SPG with MOG can predict the frequency of migraine and the degree of vestibular dysfunction. Therefore, these neuroimaging features could be potential mechanisms and therapeutic targets for developing vestibular dysfunction in migraine.https://www.frontiersin.org/articles/10.3389/fnmol.2023.1153641/fullmigrainechronificationvestibular dysfunctionfunctional connectivitymultisensory integrationresting-state functional magnetic resonance |
| spellingShingle | Liang Dong Xiaoping Fan Yulan Fan Ximao Li Hui Li Jiying Zhou Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction Frontiers in Molecular Neuroscience migraine chronification vestibular dysfunction functional connectivity multisensory integration resting-state functional magnetic resonance |
| title | Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction |
| title_full | Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction |
| title_fullStr | Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction |
| title_full_unstemmed | Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction |
| title_short | Impairments to the multisensory integration brain regions during migraine chronification: correlation with the vestibular dysfunction |
| title_sort | impairments to the multisensory integration brain regions during migraine chronification correlation with the vestibular dysfunction |
| topic | migraine chronification vestibular dysfunction functional connectivity multisensory integration resting-state functional magnetic resonance |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1153641/full |
| work_keys_str_mv | AT liangdong impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction AT xiaopingfan impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction AT yulanfan impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction AT ximaoli impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction AT huili impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction AT jiyingzhou impairmentstothemultisensoryintegrationbrainregionsduringmigrainechronificationcorrelationwiththevestibulardysfunction |