Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene

Case report: Complete and durable response to larotrectinib (TRK inhibitor) in an infant diagnosed with angiosarcoma harbouring a KHDRBS1-NTRK3 fusion gene

Significant improvements in the survival rates of paediatric cancer have been achieved over the past decade owing to recent advances in therapeutic and diagnostic strategies. However, disease progression and relapse remain a major challenge for the clinical management of paediatric angiosarcoma. Com...

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Bibliographic Details
Main Authors: Catherine Cervi, Zoltán Sápi, Gábor Bedics, Erik Zajta, Lajos Hegyi, Judit Pápay, Katalin Dezső, Edit Varga, Katalin Mudra, Csaba Bödör, Monika Csóka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Oncology
Subjects:
precision oncology
next-generation sequencing (NGS)
comprehensive genomic profiling (CGP)
paediatric soft tissue sarcoma
angiosarcoma
neurotrophic tyrosine receptor kinase (NTRK)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.999810/full

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