Cas9-mediated endogenous plasmid loss in Borrelia burgdorferi.
The spirochete Borrelia burgdorferi, which causes Lyme disease, has the most segmented genome among known bacteria. In addition to a linear chromosome, the B. burgdorferi genome contains over 20 linear and circular endogenous plasmids. While many of these plasmids are dispensable under in vitro cult...
Main Authors: | Constantin N Takacs, Yuko Nakajima, James E Haber, Christine Jacobs-Wagner |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2022-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0278151 |
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