Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation
The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detec...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/13/1/60 |
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| author | Fu-Lun Chen Li-Dan Shang Yen-Chung Lin Bo-Yen Chang Yu-Cheng Hsiao |
| author_facet | Fu-Lun Chen Li-Dan Shang Yen-Chung Lin Bo-Yen Chang Yu-Cheng Hsiao |
| author_sort | Fu-Lun Chen |
| collection | DOAJ |
| description | The early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications. |
| first_indexed | 2024-03-09T13:25:35Z |
| format | Article |
| id | doaj.art-b6178f3a98804c2db6754baa5ed03545 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:25:35Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-b6178f3a98804c2db6754baa5ed035452023-11-30T21:24:55ZengMDPI AGBiosensors2079-63742022-12-011316010.3390/bios13010060Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye ObservationFu-Lun Chen0Li-Dan Shang1Yen-Chung Lin2Bo-Yen Chang3Yu-Cheng Hsiao4Department of Internal Medicine, Division of Infectious Diseases, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Rd., Wenshan Dist., Taipei 11600, TaiwanDepartment of Geography and Planning, University of Liverpool, Liverpool L69 3BX, UKDepartment of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, 250 Wuxing St., Taipei 11031, TaiwanDepartment of Biomedical Engineering, Taipei Medical University, Taipei 11031, TaiwanGraduate Institute of Biomedical Optomechatronics, College of Biomedical Engineering, Taipei 11031, TaiwanThe early diagnosis of acute myocardial infarction is difficult in patients with nondiagnostic characteristics. Acute myocardial infarction with chest pain is associated with increased mortality. This study developed a portable test kit based on cholesteric liquid crystals (CLCs) for the rapid detection of AMI through eye observation at home. The test kit was established on dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride-coated substrates covered by a CLC-binding antibody. Cardiac troponin I (cTnI) is a major biomarker of myocardial cellular injury in human blood. The data showed that the concentration of cTnI was related to light transmittance in a positive way. The proposed CLC test kit can be operated with a smartphone; therefore, it has high potential for use as a point-of-care device for home testing. Moreover, the CLC test kit is an effective and innovative device for the rapid testing of acute myocardial infarction-related diseases through eye observation, spectrometer, or even smartphone applications.https://www.mdpi.com/2079-6374/13/1/60acute myocardial infarction rapid testcholesteric liquid crystalcardiac troponin I (cTnI) |
| spellingShingle | Fu-Lun Chen Li-Dan Shang Yen-Chung Lin Bo-Yen Chang Yu-Cheng Hsiao Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation Biosensors acute myocardial infarction rapid test cholesteric liquid crystal cardiac troponin I (cTnI) |
| title | Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation |
| title_full | Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation |
| title_fullStr | Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation |
| title_full_unstemmed | Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation |
| title_short | Label-Free, Portable, and Color-Indicating Cholesteric Liquid Crystal Test Kit for Acute Myocardial Infarction by Spectral Analysis and Naked-Eye Observation |
| title_sort | label free portable and color indicating cholesteric liquid crystal test kit for acute myocardial infarction by spectral analysis and naked eye observation |
| topic | acute myocardial infarction rapid test cholesteric liquid crystal cardiac troponin I (cTnI) |
| url | https://www.mdpi.com/2079-6374/13/1/60 |
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