Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy
There are international protocols for the management of hypothyroidism induced by autoimmune thyroid disease during pregnancy. In this descriptive study, we analyzed the implementation of international protocols regarding these pathologies, in local clinical practice. Analyzing the cases admitted to...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Media Med Publicis
2021-12-01
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| Series: | Modern Medicine |
| Subjects: | |
| Online Access: | https://medicinamoderna.ro/wp-content/uploads/2021/12/Pandora-s-Box-Autoimmune-Hypothyroidism-Treatment-During-Pregnancy-6.pdf |
| _version_ | 1819178136264245248 |
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| author | Florina-Paula PAULET Claudia MEHEDINTU Marina ANTONOVICI Monica Mihaela CIRSTOIU |
| author_facet | Florina-Paula PAULET Claudia MEHEDINTU Marina ANTONOVICI Monica Mihaela CIRSTOIU |
| author_sort | Florina-Paula PAULET |
| collection | DOAJ |
| description | There are international protocols for the management of hypothyroidism induced by autoimmune thyroid disease during pregnancy. In this descriptive study, we analyzed the implementation of international protocols regarding these pathologies, in local clinical practice. Analyzing the cases admitted to the Obstetrics and Gynecology department of Bucharest University Emergency Hospital on a period of 55 months, we identified the pregnancies with autoimmune hypothyroidism treated with Levothyroxine (LT4). We determined the prevalence of specific immunological markers for autoimmune hypothyroidism in pregnant women, we analyzed whether they are associated with distinct clinical phenotypes and ultrasound characteristics, and also, we evaluated the treatment of choice. Measurement of thyroglobulin antibodies, thyroid peroxidase antibodies, Thyroid-Stimulating Hormone, free fractions of Triiodothyronine and Thyroxine with substitute treatment instituted early (in the first 2 weeks postnatal) determine the normalization of cognitive development, especially in areas known for iodine deficiency, including Romania. |
| first_indexed | 2024-12-22T21:37:45Z |
| format | Article |
| id | doaj.art-b6196b8f648044b6b09b615b5507ccbe |
| institution | Directory Open Access Journal |
| issn | 1223-0472 2360-2473 |
| language | English |
| last_indexed | 2024-12-22T21:37:45Z |
| publishDate | 2021-12-01 |
| publisher | Media Med Publicis |
| record_format | Article |
| series | Modern Medicine |
| spelling | doaj.art-b6196b8f648044b6b09b615b5507ccbe2022-12-21T18:11:42ZengMedia Med PublicisModern Medicine1223-04722360-24732021-12-01284401405https://doi.org/10.31689/rmm.2021.28.4.401Pandora’s Box: Autoimmune Hypothyroidism Treatment During PregnancyFlorina-Paula PAULET0Claudia MEHEDINTU1https://orcid.org/0000-0001-5231-2848Marina ANTONOVICI2Monica Mihaela CIRSTOIU3https://orcid.org/0000-0002-4063-5057Doctoral School of „Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaDepartment of Obstetrics and Gynecology, „Nicolae Malaxa” Clinical Hospital, Bucharest, Romania„Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaThere are international protocols for the management of hypothyroidism induced by autoimmune thyroid disease during pregnancy. In this descriptive study, we analyzed the implementation of international protocols regarding these pathologies, in local clinical practice. Analyzing the cases admitted to the Obstetrics and Gynecology department of Bucharest University Emergency Hospital on a period of 55 months, we identified the pregnancies with autoimmune hypothyroidism treated with Levothyroxine (LT4). We determined the prevalence of specific immunological markers for autoimmune hypothyroidism in pregnant women, we analyzed whether they are associated with distinct clinical phenotypes and ultrasound characteristics, and also, we evaluated the treatment of choice. Measurement of thyroglobulin antibodies, thyroid peroxidase antibodies, Thyroid-Stimulating Hormone, free fractions of Triiodothyronine and Thyroxine with substitute treatment instituted early (in the first 2 weeks postnatal) determine the normalization of cognitive development, especially in areas known for iodine deficiency, including Romania.https://medicinamoderna.ro/wp-content/uploads/2021/12/Pandora-s-Box-Autoimmune-Hypothyroidism-Treatment-During-Pregnancy-6.pdfhypothyroidismpregnancyneonatal prognosislevothyroxine |
| spellingShingle | Florina-Paula PAULET Claudia MEHEDINTU Marina ANTONOVICI Monica Mihaela CIRSTOIU Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy Modern Medicine hypothyroidism pregnancy neonatal prognosis levothyroxine |
| title | Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy |
| title_full | Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy |
| title_fullStr | Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy |
| title_full_unstemmed | Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy |
| title_short | Pandora’s Box: Autoimmune Hypothyroidism Treatment During Pregnancy |
| title_sort | pandora s box autoimmune hypothyroidism treatment during pregnancy |
| topic | hypothyroidism pregnancy neonatal prognosis levothyroxine |
| url | https://medicinamoderna.ro/wp-content/uploads/2021/12/Pandora-s-Box-Autoimmune-Hypothyroidism-Treatment-During-Pregnancy-6.pdf |
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