The aging mouse CNS is protected by an autophagy-dependent microglia population promoted by IL-34
Abstract Microglia harness an unutilized health-promoting potential in age-related neurodegenerative and neuroinflammatory diseases, conditions like progressive multiple sclerosis (MS). Our research unveils an microglia population emerging in the cortical brain regions of aging mice, marked by ERK1/...
Main Authors: | Rasmus Berglund, Yufei Cheng, Eliane Piket, Milena Z. Adzemovic, Manuel Zeitelhofer, Tomas Olsson, Andre Ortlieb Guerreiro-Cacais, Maja Jagodic |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2024-01-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-44556-6 |
Similar Items
-
Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats
by: Gonçalo Castelo-Branco, et al.
Published: (2014-11-01) -
Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)
by: Sonja Hochmeister, et al.
Published: (2020-11-01) -
Correction: Imatinib Ameliorates Neuroinflammation in a Rat Model of Multiple Sclerosis by Enhancing Blood-Brain Barrier Integrity and by Modulating the Peripheral Immune Response.
by: Milena Z. Adzemovic, et al.
Published: (2013-01-01) -
Imatinib ameliorates neuroinflammation in a rat model of multiple sclerosis by enhancing blood-brain barrier integrity and by modulating the peripheral immune response.
by: Milena V Adzemovic, et al.
Published: (2013-01-01) -
Editorial: Neuropathology of Autoimmune Inflammatory Demyelination Disorders
by: Manuel Zeitelhofer, et al.
Published: (2022-06-01)