A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital
We investigated antibiotic resistance pattern in clinical bacterial pathogens isolated from in-patients and out-patients, and compared it with non-clinical bacterial isolates. 475 bacterial strains isolated from patients were examined for antibiotic resistance. Staphylococcus spp. (148; 31.1%) were...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1383989/full |
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| author | Vishal L. Handa Bhoomi N. Patel Dr. Arpita Bhattacharya Ramesh K. Kothari Dr. Ghanshyam Kavathia B. R. M. Vyas |
| author_facet | Vishal L. Handa Bhoomi N. Patel Dr. Arpita Bhattacharya Ramesh K. Kothari Dr. Ghanshyam Kavathia B. R. M. Vyas |
| author_sort | Vishal L. Handa |
| collection | DOAJ |
| description | We investigated antibiotic resistance pattern in clinical bacterial pathogens isolated from in-patients and out-patients, and compared it with non-clinical bacterial isolates. 475 bacterial strains isolated from patients were examined for antibiotic resistance. Staphylococcus spp. (148; 31.1%) were found to be the most prevalent, followed by Klebsiella pneumoniae (135; 28.4%), Escherichia coli (74; 15.5%), Pseudomonas aeruginosa (65; 13.6%), Enterobacter spp. (28; 5.8%), and Acinetobacter spp. (25; 5.2%). Drug-resistant bacteria isolated were extended spectrum-β-lactamase K. pneumoniae (8.8%), E. coli (20%), metallo-β-lactamase P. aeruginosa (14; 2.9%), erythromycin-inducing clindamycin resistant (7.4%), and methicillin-resistant Staphylococcus species (21.6%). Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non-clinical P. aeruginosa and K. pneumoniae strains were more antibiotic-susceptible. Our research assisted in identifying the drugs that can be used to control infections caused by antimicrobial resistant bacteria in the population and in monitoring the prevalence of drug-resistant bacterial pathogens. |
| first_indexed | 2024-04-24T08:10:54Z |
| format | Article |
| id | doaj.art-b61f070f0c1d4d6b96cd4a780a91084d |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-24T08:10:54Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-b61f070f0c1d4d6b96cd4a780a91084d2024-04-17T04:57:17ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-04-011510.3389/fmicb.2024.13839891383989A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospitalVishal L. Handa0Bhoomi N. Patel1Dr. Arpita Bhattacharya2Ramesh K. Kothari3Dr. Ghanshyam Kavathia4B. R. M. Vyas5Department of Biosciences, Saurashtra University, Rajkot, Gujarat, IndiaDepartment of Biosciences, Saurashtra University, Rajkot, Gujarat, IndiaDepartment of Microbiology, Pandit Deendayal Upadhyay Medical College, Rajkot, Gujarat, IndiaDepartment of Biosciences, Saurashtra University, Rajkot, Gujarat, IndiaDepartment of Microbiology, Pandit Deendayal Upadhyay Medical College, Rajkot, Gujarat, IndiaDepartment of Biosciences, Saurashtra University, Rajkot, Gujarat, IndiaWe investigated antibiotic resistance pattern in clinical bacterial pathogens isolated from in-patients and out-patients, and compared it with non-clinical bacterial isolates. 475 bacterial strains isolated from patients were examined for antibiotic resistance. Staphylococcus spp. (148; 31.1%) were found to be the most prevalent, followed by Klebsiella pneumoniae (135; 28.4%), Escherichia coli (74; 15.5%), Pseudomonas aeruginosa (65; 13.6%), Enterobacter spp. (28; 5.8%), and Acinetobacter spp. (25; 5.2%). Drug-resistant bacteria isolated were extended spectrum-β-lactamase K. pneumoniae (8.8%), E. coli (20%), metallo-β-lactamase P. aeruginosa (14; 2.9%), erythromycin-inducing clindamycin resistant (7.4%), and methicillin-resistant Staphylococcus species (21.6%). Pathogens belonging to the Enterobacteriaceae family were observed to undergo directional selection developing resistance against antibiotics ciprofloxacin, piperacillin-tazobactam, cefepime, and cefuroxime. Pathogens in the surgical ward exhibited higher levels of antibiotic resistance, while non-clinical P. aeruginosa and K. pneumoniae strains were more antibiotic-susceptible. Our research assisted in identifying the drugs that can be used to control infections caused by antimicrobial resistant bacteria in the population and in monitoring the prevalence of drug-resistant bacterial pathogens.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1383989/fullantimicrobial resistanceextended spectrum-β-lactamasemethicillin-resistant Staphylococcus aureusmetallo-β-lactamaseerythromycin-induced clindamycin resistance |
| spellingShingle | Vishal L. Handa Bhoomi N. Patel Dr. Arpita Bhattacharya Ramesh K. Kothari Dr. Ghanshyam Kavathia B. R. M. Vyas A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital Frontiers in Microbiology antimicrobial resistance extended spectrum-β-lactamase methicillin-resistant Staphylococcus aureus metallo-β-lactamase erythromycin-induced clindamycin resistance |
| title | A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| title_full | A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| title_fullStr | A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| title_full_unstemmed | A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| title_short | A study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| title_sort | study of antibiotic resistance pattern of clinical bacterial pathogens isolated from patients in a tertiary care hospital |
| topic | antimicrobial resistance extended spectrum-β-lactamase methicillin-resistant Staphylococcus aureus metallo-β-lactamase erythromycin-induced clindamycin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1383989/full |
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