Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Abstract Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor. We urgently need to develop new therapies with safe long-term toxicity profiles for...

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Bibliographic Details
Main Authors: Annie Beaudry, Simon Jacques-Ricard, Anaïs Darracq, Nicolas Sgarioto, Araceli Garcia, Teresita Rode García, William Lemieux, Kathie Béland, Elie Haddad, Paulo Cordeiro, Michel Duval, Serge McGraw, Chantal Richer, Maxime Caron, François Marois, Pascal St-Onge, Daniel Sinnett, Xavier Banquy, Noël J.-M. Raynal
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-43219-2

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https://doi.org/10.1038/s41598-023-43219-2

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