Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene

Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene

Maturation of microRNAs (miRNAs) begins by the “Microprocessor” complex, containing the Drosha endonuclease and its partner protein, "DiGeorge Syndrome Critical Region 8" (DGCR8). Although the main function of the two proteins is to coordinate the first step of precursor miRNAs formation,...

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Bibliographic Details
Main Authors: Dóra Reé, Ábel Fóthi, Nóra Varga, Orsolya Kolacsek, Tamás I. Orbán, Ágota Apáti
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Genes
Subjects:
miRNA processing
C19MC
miRNA cluster
human pluripotent stem cells
differentiation
Online Access:https://www.mdpi.com/2073-4425/13/11/1925

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