Extracellular Citrate Treatment Induces HIF1α Degradation and Inhibits the Growth of Low-Glycolytic Hepatocellular Carcinoma under Hypoxia

Extracellular Citrate Treatment Induces HIF1α Degradation and Inhibits the Growth of Low-Glycolytic Hepatocellular Carcinoma under Hypoxia

HCC is well known for low glycolysis in the tumors, whereas hypoxia induces glycolytic phenotype and tumor progression. This study was conducted to evaluate the expression of SLCs in human HCCs and investigated whether extracellular nutrient administration related to SLCs in low-glycolytic HCC can p...

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Bibliographic Details
Main Authors: Seon Yoo Kim, Dongwoo Kim, Jisu Kim, Hae Young Ko, Won Jin Kim, Youngjoo Park, Hye Won Lee, Dai Hoon Han, Kyung Sik Kim, Sunghyouk Park, Misu Lee, Mijin Yun
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
<i>SLC13A5</i>/NaCT
citrate
cancer metabolism
hepatocellular carcinoma
hypoxia
Online Access:https://www.mdpi.com/2072-6694/14/14/3355

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