Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study
Objectives: We examined the safety and clinical outcomes of outpatient parenteral antibiotic therapy (OPAT) for patients with infective endocarditis (IE) in Christchurch, New Zealand. Methods: Demographic and clinical data were collected from all adult patients treated for IE over 5 years. Outcomes...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223006306 |
| _version_ | 1827875763735494656 |
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| author | Patrick O. Campbell Kate Gallagher Simon C. Dalton Sarah C.L. Metcalf Nicholas M. Douglas Stephen T. Chambers |
| author_facet | Patrick O. Campbell Kate Gallagher Simon C. Dalton Sarah C.L. Metcalf Nicholas M. Douglas Stephen T. Chambers |
| author_sort | Patrick O. Campbell |
| collection | DOAJ |
| description | Objectives: We examined the safety and clinical outcomes of outpatient parenteral antibiotic therapy (OPAT) for patients with infective endocarditis (IE) in Christchurch, New Zealand. Methods: Demographic and clinical data were collected from all adult patients treated for IE over 5 years. Outcomes were stratified by receipt of at least partial OPAT vs entirely hospital-based parenteral therapy. Results: There were 172 episodes of IE between 2014 and 2018. OPAT was administered in 115 cases (67%) for a median of 27 days after a median of 12 days of inpatient treatment. In the OPAT cohort, viridans group streptococci were the commonest causative pathogens (35%) followed by Staphylococcus aureus (25%) and Enterococcus faecalis (11%). There were six (5%) antibiotic-related adverse events and 26 (23%) readmissions in the OPAT treatment group. Mortality in OPAT patients was 6% (7/115) at 6 months and 10% (11/114) at 1 year and for patients receiving wholly inpatient parenteral therapy was 56% (31/56) and 58% (33/56), respectively. Three patients (3%) in the OPAT group had a relapse of IE during the 1-year follow-up period. Conclusion: OPAT can be used safely in patients with IE, even in selected cases with complicated or difficult-to-treat infections. |
| first_indexed | 2024-03-12T17:12:39Z |
| format | Article |
| id | doaj.art-b629a98e9c874921abe7e2bcf41cbf7e |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-03-12T17:12:39Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-b629a98e9c874921abe7e2bcf41cbf7e2023-08-06T04:36:44ZengElsevierInternational Journal of Infectious Diseases1201-97122023-09-01134172176Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort studyPatrick O. Campbell0Kate Gallagher1Simon C. Dalton2Sarah C.L. Metcalf3Nicholas M. Douglas4Stephen T. Chambers5Department of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New Zealand; Corresponding author:Department of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New ZealandDepartment of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New ZealandDepartment of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New ZealandDepartment of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New Zealand; Division of Medicine, University of Otago, Christchurch, New Zealand; Division of Global and Tropical Health, Menzies School of Health Research, Charles Darwin University, Darwin, AustraliaDepartment of Infectious Diseases, Christchurch Hospital, Te Whatu Ora Waitaha Canterbury, New Zealand; Department of Pathology and Biomedical Science, University of Otago, Christchurch, New ZealandObjectives: We examined the safety and clinical outcomes of outpatient parenteral antibiotic therapy (OPAT) for patients with infective endocarditis (IE) in Christchurch, New Zealand. Methods: Demographic and clinical data were collected from all adult patients treated for IE over 5 years. Outcomes were stratified by receipt of at least partial OPAT vs entirely hospital-based parenteral therapy. Results: There were 172 episodes of IE between 2014 and 2018. OPAT was administered in 115 cases (67%) for a median of 27 days after a median of 12 days of inpatient treatment. In the OPAT cohort, viridans group streptococci were the commonest causative pathogens (35%) followed by Staphylococcus aureus (25%) and Enterococcus faecalis (11%). There were six (5%) antibiotic-related adverse events and 26 (23%) readmissions in the OPAT treatment group. Mortality in OPAT patients was 6% (7/115) at 6 months and 10% (11/114) at 1 year and for patients receiving wholly inpatient parenteral therapy was 56% (31/56) and 58% (33/56), respectively. Three patients (3%) in the OPAT group had a relapse of IE during the 1-year follow-up period. Conclusion: OPAT can be used safely in patients with IE, even in selected cases with complicated or difficult-to-treat infections.http://www.sciencedirect.com/science/article/pii/S1201971223006306Infective endocarditisOutpatient parenteral antibiotic treatmentHome intravenous antibiotic treatmentChristchurchNew Zealand |
| spellingShingle | Patrick O. Campbell Kate Gallagher Simon C. Dalton Sarah C.L. Metcalf Nicholas M. Douglas Stephen T. Chambers Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study International Journal of Infectious Diseases Infective endocarditis Outpatient parenteral antibiotic treatment Home intravenous antibiotic treatment Christchurch New Zealand |
| title | Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study |
| title_full | Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study |
| title_fullStr | Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study |
| title_full_unstemmed | Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study |
| title_short | Safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in Christchurch, New Zealand: A retrospective cohort study |
| title_sort | safety and clinical outcomes of outpatient parenteral antibiotic therapy for infective endocarditis in christchurch new zealand a retrospective cohort study |
| topic | Infective endocarditis Outpatient parenteral antibiotic treatment Home intravenous antibiotic treatment Christchurch New Zealand |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223006306 |
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