Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

Combinatorial bZIP dimers display complex DNA-binding specificity landscapes

How transcription factor dimerization impacts DNA-binding specificity is poorly understood. Guided by protein dimerization properties, we examined DNA binding specificities of 270 human bZIP pairs. DNA interactomes of 80 heterodimers and 22 homodimers revealed that 72% of heterodimer motifs correspo...

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Bibliographic Details
Main Authors: José A Rodríguez-Martínez, Aaron W Reinke, Devesh Bhimsaria, Amy E Keating, Aseem Z Ansari
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
protein-DNA interactions
transcription factors
sequence specificity landscapes
genetic variants
SELEX
gene regulation
Online Access:https://elifesciences.org/articles/19272

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