IFN-γ, should not be ignored in SLE
Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex pathogenesis and genetic predisposition. With continued understanding of this disease, it was found that SLE is related to the interferon gene signature. Most studies have emphasized the important role of IFN-α in SLE,...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954706/full |
| _version_ | 1798037799350304768 |
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| author | Wenping Liu Shumin Zhang Jibo Wang |
| author_facet | Wenping Liu Shumin Zhang Jibo Wang |
| author_sort | Wenping Liu |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex pathogenesis and genetic predisposition. With continued understanding of this disease, it was found that SLE is related to the interferon gene signature. Most studies have emphasized the important role of IFN-α in SLE, but our previous study suggested a nonnegligible role of IFN-γ in SLE. Some scholars previously found that IFN-γ is abnormally elevated as early as before the classification of SLE and before the emergence of autoantibodies and IFN-α. Due to the large overlap between IFN-α and IFN-γ, SLE is mostly characterized by expression of the IFN-α gene after onset. Therefore, the role of IFN-γ in SLE may be underestimated. This article mainly reviews the role of IFN-γ in SLE and focuses on the nonnegligible role of IFN-γ in SLE to gain a more comprehensive understanding of the disease. |
| first_indexed | 2024-04-11T21:31:29Z |
| format | Article |
| id | doaj.art-b62d4a07443240139d4015ec4a090c19 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T21:31:29Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-b62d4a07443240139d4015ec4a090c192022-12-22T04:01:59ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.954706954706IFN-γ, should not be ignored in SLEWenping LiuShumin ZhangJibo WangSystemic lupus erythematosus (SLE) is a typical autoimmune disease with a complex pathogenesis and genetic predisposition. With continued understanding of this disease, it was found that SLE is related to the interferon gene signature. Most studies have emphasized the important role of IFN-α in SLE, but our previous study suggested a nonnegligible role of IFN-γ in SLE. Some scholars previously found that IFN-γ is abnormally elevated as early as before the classification of SLE and before the emergence of autoantibodies and IFN-α. Due to the large overlap between IFN-α and IFN-γ, SLE is mostly characterized by expression of the IFN-α gene after onset. Therefore, the role of IFN-γ in SLE may be underestimated. This article mainly reviews the role of IFN-γ in SLE and focuses on the nonnegligible role of IFN-γ in SLE to gain a more comprehensive understanding of the disease.https://www.frontiersin.org/articles/10.3389/fimmu.2022.954706/fullIFN-γsystemic lupus erythematosusautoimmunebiologic therapyimmune cells |
| spellingShingle | Wenping Liu Shumin Zhang Jibo Wang IFN-γ, should not be ignored in SLE Frontiers in Immunology IFN-γ systemic lupus erythematosus autoimmune biologic therapy immune cells |
| title | IFN-γ, should not be ignored in SLE |
| title_full | IFN-γ, should not be ignored in SLE |
| title_fullStr | IFN-γ, should not be ignored in SLE |
| title_full_unstemmed | IFN-γ, should not be ignored in SLE |
| title_short | IFN-γ, should not be ignored in SLE |
| title_sort | ifn γ should not be ignored in sle |
| topic | IFN-γ systemic lupus erythematosus autoimmune biologic therapy immune cells |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.954706/full |
| work_keys_str_mv | AT wenpingliu ifngshouldnotbeignoredinsle AT shuminzhang ifngshouldnotbeignoredinsle AT jibowang ifngshouldnotbeignoredinsle |