Plant Defensins from a Structural Perspective

Plant defensins form a family of proteins with a broad spectrum of protective activities against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed anticancer activity. In general, plant defensins are non-toxic to plant and mammalian cells, and interest in using them for b...

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Main Authors: Valentina Kovaleva, Irina Bukhteeva, Oleg Y. Kit, Irina V. Nesmelova
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/15/5307
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author Valentina Kovaleva
Irina Bukhteeva
Oleg Y. Kit
Irina V. Nesmelova
author_facet Valentina Kovaleva
Irina Bukhteeva
Oleg Y. Kit
Irina V. Nesmelova
author_sort Valentina Kovaleva
collection DOAJ
description Plant defensins form a family of proteins with a broad spectrum of protective activities against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed anticancer activity. In general, plant defensins are non-toxic to plant and mammalian cells, and interest in using them for biotechnological and medicinal purposes is growing. Recent studies provided significant insights into the mechanisms of action of plant defensins. In this review, we focus on structural and dynamics aspects and discuss structure-dynamics-function relations of plant defensins.
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spelling doaj.art-b62dccc4180245ed8f9763837529c5eb2023-11-20T08:01:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-07-012115530710.3390/ijms21155307Plant Defensins from a Structural PerspectiveValentina Kovaleva0Irina Bukhteeva1Oleg Y. Kit2Irina V. Nesmelova3Laboratory of Molecular Genetic Markers in Plants, Ukrainian National Forestry University, 79057 Lviv, UkraineDepartment of Physics and Optical Sciences and Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USAInterregional Academy of Personal Management, 79059 Lviv, UkraineDepartment of Physics and Optical Sciences and Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USAPlant defensins form a family of proteins with a broad spectrum of protective activities against fungi, bacteria, and insects. Furthermore, some plant defensins have revealed anticancer activity. In general, plant defensins are non-toxic to plant and mammalian cells, and interest in using them for biotechnological and medicinal purposes is growing. Recent studies provided significant insights into the mechanisms of action of plant defensins. In this review, we focus on structural and dynamics aspects and discuss structure-dynamics-function relations of plant defensins.https://www.mdpi.com/1422-0067/21/15/5307plant defensinstructuredynamicsγ-coreNMRx-ray
spellingShingle Valentina Kovaleva
Irina Bukhteeva
Oleg Y. Kit
Irina V. Nesmelova
Plant Defensins from a Structural Perspective
International Journal of Molecular Sciences
plant defensin
structure
dynamics
γ-core
NMR
x-ray
title Plant Defensins from a Structural Perspective
title_full Plant Defensins from a Structural Perspective
title_fullStr Plant Defensins from a Structural Perspective
title_full_unstemmed Plant Defensins from a Structural Perspective
title_short Plant Defensins from a Structural Perspective
title_sort plant defensins from a structural perspective
topic plant defensin
structure
dynamics
γ-core
NMR
x-ray
url https://www.mdpi.com/1422-0067/21/15/5307
work_keys_str_mv AT valentinakovaleva plantdefensinsfromastructuralperspective
AT irinabukhteeva plantdefensinsfromastructuralperspective
AT olegykit plantdefensinsfromastructuralperspective
AT irinavnesmelova plantdefensinsfromastructuralperspective