Do All Patients Require Radiotherapy after Breast-Conserving Surgery?
Radiotherapy following breast conservation is routine in the treatment of breast cancer. This creates a large demand for radiotherapy services with implicit cost effects and potential morbidity to patients. Radiotherapy is administered to decrease local recurrence, but is radiotherapy required for a...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2010-04-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/2/2/740/ |
| _version_ | 1797725075320864768 |
|---|---|
| author | G. Bruce Mann Anita R. Skandarajah |
| author_facet | G. Bruce Mann Anita R. Skandarajah |
| author_sort | G. Bruce Mann |
| collection | DOAJ |
| description | Radiotherapy following breast conservation is routine in the treatment of breast cancer. This creates a large demand for radiotherapy services with implicit cost effects and potential morbidity to patients. Radiotherapy is administered to decrease local recurrence, but is radiotherapy required for all breast cancers? A literature search using the Medline and Ovid databases was conducted between 1965 and 2010 using the terms ‘role of radiotherapy’, ‘early breast cancer’, and omission of radiotherapy’. Papers with clinical trials published in English in adult humans were included. Fourteen randomized controlled trials were included. Local recurrence rates range from 0.8–35% in patients in whom radiotherapy was omitted. Low risk characteristics include older age, small tumor size, no lymphovascular invasion and low to moderate grade. At present, there is no clearly defined low risk group of patients in whom radiotherapy can be omitted. |
| first_indexed | 2024-03-12T10:25:55Z |
| format | Article |
| id | doaj.art-b62f3119c47244089b73c5a1dca93af6 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T10:25:55Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b62f3119c47244089b73c5a1dca93af62023-09-02T09:43:27ZengMDPI AGCancers2072-66942010-04-012274075110.3390/cancers2020740Do All Patients Require Radiotherapy after Breast-Conserving Surgery?G. Bruce MannAnita R. SkandarajahRadiotherapy following breast conservation is routine in the treatment of breast cancer. This creates a large demand for radiotherapy services with implicit cost effects and potential morbidity to patients. Radiotherapy is administered to decrease local recurrence, but is radiotherapy required for all breast cancers? A literature search using the Medline and Ovid databases was conducted between 1965 and 2010 using the terms ‘role of radiotherapy’, ‘early breast cancer’, and omission of radiotherapy’. Papers with clinical trials published in English in adult humans were included. Fourteen randomized controlled trials were included. Local recurrence rates range from 0.8–35% in patients in whom radiotherapy was omitted. Low risk characteristics include older age, small tumor size, no lymphovascular invasion and low to moderate grade. At present, there is no clearly defined low risk group of patients in whom radiotherapy can be omitted.http://www.mdpi.com/2072-6694/2/2/740/breast conservative therapyradiotherapyipsilateral breast tumor recurrence |
| spellingShingle | G. Bruce Mann Anita R. Skandarajah Do All Patients Require Radiotherapy after Breast-Conserving Surgery? Cancers breast conservative therapy radiotherapy ipsilateral breast tumor recurrence |
| title | Do All Patients Require Radiotherapy after Breast-Conserving Surgery? |
| title_full | Do All Patients Require Radiotherapy after Breast-Conserving Surgery? |
| title_fullStr | Do All Patients Require Radiotherapy after Breast-Conserving Surgery? |
| title_full_unstemmed | Do All Patients Require Radiotherapy after Breast-Conserving Surgery? |
| title_short | Do All Patients Require Radiotherapy after Breast-Conserving Surgery? |
| title_sort | do all patients require radiotherapy after breast conserving surgery |
| topic | breast conservative therapy radiotherapy ipsilateral breast tumor recurrence |
| url | http://www.mdpi.com/2072-6694/2/2/740/ |
| work_keys_str_mv | AT gbrucemann doallpatientsrequireradiotherapyafterbreastconservingsurgery AT anitarskandarajah doallpatientsrequireradiotherapyafterbreastconservingsurgery |