Molecular functions and specific roles of circRNAs in the cardiovascular system
As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge about circRNAs in cardiovascular disease. CircRNAs are not only associated with different type...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2018-06-01
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| Series: | Non-coding RNA Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468054017300501 |
| _version_ | 1797203660347801600 |
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| author | Lesca M. Holdt Alexander Kohlmaier Daniel Teupser |
| author_facet | Lesca M. Holdt Alexander Kohlmaier Daniel Teupser |
| author_sort | Lesca M. Holdt |
| collection | DOAJ |
| description | As part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge about circRNAs in cardiovascular disease. CircRNAs are not only associated with different types of cardiovascular disease, but they have also been identified as intracellular effector molecules for pathophysiological changes in cardiovascular tissues, and as cardiovascular biomarkers. This evidence is put in the context of the current understanding of general circRNA biogenesis and of known interactions of circRNAs with DNA, RNA, and proteins. |
| first_indexed | 2024-04-24T08:22:52Z |
| format | Article |
| id | doaj.art-b6311dcf8eea4f0ba3e876007dc3ac9c |
| institution | Directory Open Access Journal |
| issn | 2468-0540 |
| language | English |
| last_indexed | 2024-04-24T08:22:52Z |
| publishDate | 2018-06-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Non-coding RNA Research |
| spelling | doaj.art-b6311dcf8eea4f0ba3e876007dc3ac9c2024-04-17T00:32:16ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402018-06-0132759810.1016/j.ncrna.2018.05.002Molecular functions and specific roles of circRNAs in the cardiovascular systemLesca M. HoldtAlexander KohlmaierDaniel TeupserAs part of the superfamily of long noncoding RNAs, circular RNAs (circRNAs) are emerging as a new type of regulatory molecules that partake in gene expression control. Here, we review the current knowledge about circRNAs in cardiovascular disease. CircRNAs are not only associated with different types of cardiovascular disease, but they have also been identified as intracellular effector molecules for pathophysiological changes in cardiovascular tissues, and as cardiovascular biomarkers. This evidence is put in the context of the current understanding of general circRNA biogenesis and of known interactions of circRNAs with DNA, RNA, and proteins.http://www.sciencedirect.com/science/article/pii/S2468054017300501Non-coding RNACircular RNAcircRNACardiovascular diseaseSplicingTranscription |
| spellingShingle | Lesca M. Holdt Alexander Kohlmaier Daniel Teupser Molecular functions and specific roles of circRNAs in the cardiovascular system Non-coding RNA Research Non-coding RNA Circular RNA circRNA Cardiovascular disease Splicing Transcription |
| title | Molecular functions and specific roles of circRNAs in the cardiovascular system |
| title_full | Molecular functions and specific roles of circRNAs in the cardiovascular system |
| title_fullStr | Molecular functions and specific roles of circRNAs in the cardiovascular system |
| title_full_unstemmed | Molecular functions and specific roles of circRNAs in the cardiovascular system |
| title_short | Molecular functions and specific roles of circRNAs in the cardiovascular system |
| title_sort | molecular functions and specific roles of circrnas in the cardiovascular system |
| topic | Non-coding RNA Circular RNA circRNA Cardiovascular disease Splicing Transcription |
| url | http://www.sciencedirect.com/science/article/pii/S2468054017300501 |
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