Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion.

Disruption of the lipid-transporting LdMT-LdRos3 complex in Leishmania donovani affects membrane lipid asymmetry but not host cell invasion.

Maintenance and regulation of the asymmetric lipid distribution across eukaryotic plasma membranes is governed by the concerted action of specific membrane proteins controlling lipid movement across the bilayer. Here, we show that the miltefosine transporter (LdMT), a member of the P4-ATPase subfami...

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Bibliographic Details
Main Authors: Adrien Weingärtner, Björn Drobot, Andreas Herrmann, María P Sánchez-Cañete, Francisco Gamarro, Santiago Castanys, Thomas Günther Pomorski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2928753?pdf=render

Internet

http://europepmc.org/articles/PMC2928753?pdf=render

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