Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm
Background: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflamma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/5/1182 |
| _version_ | 1797474801933090816 |
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| author | Ida Åström Malm Rachel De Basso Peter Blomstrand Dick Wågsäter |
| author_facet | Ida Åström Malm Rachel De Basso Peter Blomstrand Dick Wågsäter |
| author_sort | Ida Åström Malm |
| collection | DOAJ |
| description | Background: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflammatory marker levels and arterial stiffness in males with AAA. Methods: A total of 270 males (191 AAA and 79 controls) were included in the study. Arterial stiffness was assessed using non-invasive applanation tonometry to measure the regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. Blood samples were obtained, and interleukin-10 (IL-10) and CRP levels were analysed. Results: Subjects with an AAA had higher levels of IL-10 (21.5 ± 14.0 ng/mL versus 16.6 ± 9.3 ng/mL) compared to controls (<i>p</i> = 0.007). In the AAA cohort, subjects with T2DM showed higher levels of IL-10 (26.4 ± 17.3 versus 20.4 ± 13.0, <i>p</i> = 0.036). We observed a positive correlation between PWVcf and CRP in the control group (r = 0.332) but not the AAA group. PWVcf and CRP were negatively correlated (r = 0.571) in the T2DM subjects treated with metformin in the AAA group. Conclusion: Arterial stiffness is related to the degree of inflammation reflected by CRP and IL-10 levels in males with an AAA. IL-10 is negatively correlated with arterial stiffness in these subjects. This finding suggests that IL-10 may decrease arterial stiffness in males with AAA. The negative correlation between CRP and PWVcf in males with T2DM treated with metformin may indicate that metformin influences the arterial wall to decrease stiffness in subjects with AAA. |
| first_indexed | 2024-03-09T20:36:15Z |
| format | Article |
| id | doaj.art-b6323ad096424544910655929e31f740 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:36:15Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-b6323ad096424544910655929e31f7402023-11-23T23:12:01ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01115118210.3390/jcm11051182Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic AneurysmIda Åström Malm0Rachel De Basso1Peter Blomstrand2Dick Wågsäter3Department of Natural Sciences and Biomedicine, School of Health and Welfare, Jönköping University, SE-551 11 Jönköping, SwedenDepartment of Natural Sciences and Biomedicine, School of Health and Welfare, Jönköping University, SE-551 11 Jönköping, SwedenDepartment of Natural Sciences and Biomedicine, School of Health and Welfare, Jönköping University, SE-551 11 Jönköping, SwedenDepartment of Medical Cell Biology, Uppsala University, SE-751 23 Uppsala, SwedenBackground: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflammatory marker levels and arterial stiffness in males with AAA. Methods: A total of 270 males (191 AAA and 79 controls) were included in the study. Arterial stiffness was assessed using non-invasive applanation tonometry to measure the regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. Blood samples were obtained, and interleukin-10 (IL-10) and CRP levels were analysed. Results: Subjects with an AAA had higher levels of IL-10 (21.5 ± 14.0 ng/mL versus 16.6 ± 9.3 ng/mL) compared to controls (<i>p</i> = 0.007). In the AAA cohort, subjects with T2DM showed higher levels of IL-10 (26.4 ± 17.3 versus 20.4 ± 13.0, <i>p</i> = 0.036). We observed a positive correlation between PWVcf and CRP in the control group (r = 0.332) but not the AAA group. PWVcf and CRP were negatively correlated (r = 0.571) in the T2DM subjects treated with metformin in the AAA group. Conclusion: Arterial stiffness is related to the degree of inflammation reflected by CRP and IL-10 levels in males with an AAA. IL-10 is negatively correlated with arterial stiffness in these subjects. This finding suggests that IL-10 may decrease arterial stiffness in males with AAA. The negative correlation between CRP and PWVcf in males with T2DM treated with metformin may indicate that metformin influences the arterial wall to decrease stiffness in subjects with AAA.https://www.mdpi.com/2077-0383/11/5/1182arterial stiffnessabdominal aortic aneurysmdiabetes mellitus type 2inflammatory marker |
| spellingShingle | Ida Åström Malm Rachel De Basso Peter Blomstrand Dick Wågsäter Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm Journal of Clinical Medicine arterial stiffness abdominal aortic aneurysm diabetes mellitus type 2 inflammatory marker |
| title | Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm |
| title_full | Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm |
| title_fullStr | Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm |
| title_full_unstemmed | Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm |
| title_short | Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm |
| title_sort | association of il 10 and crp with pulse wave velocity in patients with abdominal aortic aneurysm |
| topic | arterial stiffness abdominal aortic aneurysm diabetes mellitus type 2 inflammatory marker |
| url | https://www.mdpi.com/2077-0383/11/5/1182 |
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