Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules.

Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules.

T-cell exhaustion seems to play a critical role in CD8+ T-cell dysfunction during chronic viral infections. However, up to now little is known about the mechanisms underlying CD4+ T-cell dysfunction during chronic hepatitis B virus (CHB) infection and the role of inhibitory molecules such as program...

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Main Authors: Bijan Raziorrouh, Malte Heeg, Peter Kurktschiev, Winfried Schraut, Reinhart Zachoval, Clemens Wendtner, Martin Wächtler, Michael Spannagl, Gerald Denk, Axel Ulsenheimer, Bertram Bengsch, Hanspeter Pircher, Helmut M Diepolder, Norbert H Grüner, Maria-Christina Jung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4140833?pdf=render

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