Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece
Group B streptococcus (GBS) remains a leading cause of neonatal disease. However, GBS rates and prevention strategies vary considerably worldwide. Herein, we investigated the burden and epidemiological trends of neonatal GBS infections in our area (Greece) over the last two decades. We conducted a m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-12-01
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| Series: | Infectious Disease Reports |
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| Online Access: | https://www.pagepress.org/journals/index.php/idr/article/view/7744 |
| _version_ | 1818979905657896960 |
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| author | Eleni Vergadi Antonia Manoura Emmanouil Chatzakis Emmanouil Karavitakis Sofia Maraki Emmanouil Galanakis |
| author_facet | Eleni Vergadi Antonia Manoura Emmanouil Chatzakis Emmanouil Karavitakis Sofia Maraki Emmanouil Galanakis |
| author_sort | Eleni Vergadi |
| collection | DOAJ |
| description | Group B streptococcus (GBS) remains a leading cause of neonatal disease. However, GBS rates and prevention strategies vary considerably worldwide. Herein, we investigated the burden and epidemiological trends of neonatal GBS infections in our area (Greece) over the last two decades. We conducted a multicenter retrospective study that includes all cases of culture-proven GBS disease in infants <90 days old in the last 22 years. Neonatal GBS incidence was 0.17/1000 live births (95%CI: 0.11-0.21). A significant increase was noted during the second decade (0.23 vs 0.10/1000, P<0.05). Late onset disease (LOD) significantly increased during the second decade (0.08 vs 0.02, P<0.05). Infants in the LOD group had a higher risk of meningitis (RR 1.8, 95%CI: 1.23-2.71). Long-term neurological sequelae were reported in 42.8% of meningitis cases. The mortality rate was 8%. The incidence of neonatal GBS disease in our area is among the lowest reported, but an increase was noted the last decade mainly due a rise in the LOD. The burden of LOD, the mortality and long-term disability are still substantial, thus effective prevention strategies − including maternal vaccination for neonatal GBS − are needed. |
| first_indexed | 2024-12-20T17:06:58Z |
| format | Article |
| id | doaj.art-b632eab6f3eb434eb6ee25b4c387a554 |
| institution | Directory Open Access Journal |
| issn | 2036-7430 2036-7449 |
| language | English |
| last_indexed | 2024-12-20T17:06:58Z |
| publishDate | 2018-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Infectious Disease Reports |
| spelling | doaj.art-b632eab6f3eb434eb6ee25b4c387a5542022-12-21T19:32:15ZengMDPI AGInfectious Disease Reports2036-74302036-74492018-12-0110310.4081/idr.2018.7744Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, GreeceEleni Vergadi0Antonia Manoura1Emmanouil Chatzakis2Emmanouil Karavitakis3Sofia Maraki4Emmanouil Galanakis5Department or Pediatrics, University of Crete, School of MedicineDepartment of Neonatology, Heraklion University HospitalDepartment of Neonatology, Venizeleion General HospitalDepartment of Neonatology, General Hospital of ChaniaDepartment of Clinical Microbiology, Heraklion University Hospital, CreteDepartment or Pediatrics, University of Crete, School of MedicineGroup B streptococcus (GBS) remains a leading cause of neonatal disease. However, GBS rates and prevention strategies vary considerably worldwide. Herein, we investigated the burden and epidemiological trends of neonatal GBS infections in our area (Greece) over the last two decades. We conducted a multicenter retrospective study that includes all cases of culture-proven GBS disease in infants <90 days old in the last 22 years. Neonatal GBS incidence was 0.17/1000 live births (95%CI: 0.11-0.21). A significant increase was noted during the second decade (0.23 vs 0.10/1000, P<0.05). Late onset disease (LOD) significantly increased during the second decade (0.08 vs 0.02, P<0.05). Infants in the LOD group had a higher risk of meningitis (RR 1.8, 95%CI: 1.23-2.71). Long-term neurological sequelae were reported in 42.8% of meningitis cases. The mortality rate was 8%. The incidence of neonatal GBS disease in our area is among the lowest reported, but an increase was noted the last decade mainly due a rise in the LOD. The burden of LOD, the mortality and long-term disability are still substantial, thus effective prevention strategies − including maternal vaccination for neonatal GBS − are needed.https://www.pagepress.org/journals/index.php/idr/article/view/7744neonatal infectionsGroup B streptococcusincidencelate onsetearly onsetintrapartum prophylaxis |
| spellingShingle | Eleni Vergadi Antonia Manoura Emmanouil Chatzakis Emmanouil Karavitakis Sofia Maraki Emmanouil Galanakis Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece Infectious Disease Reports neonatal infections Group B streptococcus incidence late onset early onset intrapartum prophylaxis |
| title | Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece |
| title_full | Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece |
| title_fullStr | Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece |
| title_full_unstemmed | Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece |
| title_short | Changes in the incidence and epidemiology of neonatal group B Streptococcal disease over the last two decades in Crete, Greece |
| title_sort | changes in the incidence and epidemiology of neonatal group b streptococcal disease over the last two decades in crete greece |
| topic | neonatal infections Group B streptococcus incidence late onset early onset intrapartum prophylaxis |
| url | https://www.pagepress.org/journals/index.php/idr/article/view/7744 |
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