Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation
Peri-implantitis is a highly prevalent disease caused by bacterial plaque that results in inflammation. The disease starts from the soft tissue and gradually spreads to the hard tissue around the implant. If left untreated, it can lead to decreased bone density and loss of the implant. Therefore, it...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S026412752300727X |
| _version_ | 1827781839705604096 |
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| author | Shengcai Qi Binbin Kang Chao Yao Dongmei Lan Xiaohong Chen Fengcang Ma Ping Liu Yuehua Liu |
| author_facet | Shengcai Qi Binbin Kang Chao Yao Dongmei Lan Xiaohong Chen Fengcang Ma Ping Liu Yuehua Liu |
| author_sort | Shengcai Qi |
| collection | DOAJ |
| description | Peri-implantitis is a highly prevalent disease caused by bacterial plaque that results in inflammation. The disease starts from the soft tissue and gradually spreads to the hard tissue around the implant. If left untreated, it can lead to decreased bone density and loss of the implant. Therefore, it is crucial to improve the antibacterial and biological activity of implants to achieve dual functions. In this study, we prepared a Ce-doped TiO2 coating on the surface of pure titanium by micro-arc oxidation (MAO) for the prevention of peri-implantitis. We systematically investigated the physicochemical properties, antibacterial activity, and biocompatibility of Ce-doped coatings in vitro and in vivo. The results demonstrated that the increase of Ce concentration in the coating could increase the proliferation, adhesion and osteogenic differentiation of BMSCs in vitro. Results from in vivo osteogenesis experiments demonstrated that the 2Ce-MAO coating exhibited superior efficacy in promoting implant repair in osteoporotic rats. Furthermore, the results of in vitro and in vivo antibacterial experiments indicated that the Ce-TiO2 coating exhibits excellent antibacterial and anti-inflammatory properties. These findings suggest that the Ce-TiO2 coating prepared via MAO may be a promising approach for preventing peri-implantitis and promoting osteogenesis in osteoporosis. |
| first_indexed | 2024-03-11T15:24:32Z |
| format | Article |
| id | doaj.art-b637f75d6f9644f5926e62fb544821eb |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-03-11T15:24:32Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-b637f75d6f9644f5926e62fb544821eb2023-10-28T05:06:24ZengElsevierMaterials & Design0264-12752023-10-01234112312Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidationShengcai Qi0Binbin Kang1Chao Yao2Dongmei Lan3Xiaohong Chen4Fengcang Ma5Ping Liu6Yuehua Liu7Department of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, ChinaDepartment of Prosthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Medical College, Anhui University of Science and Technology, Huainan, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, ChinaSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai, China; Corresponding authors.Shanghai Key Laboratory of Craniomaxill of Acial Development and Diseases, Fudan University, Shanghai, China; Department of Orthodontics, Shanghai Stomatological Hospital, Fudan University, Shanghai, China; Corresponding authors.Peri-implantitis is a highly prevalent disease caused by bacterial plaque that results in inflammation. The disease starts from the soft tissue and gradually spreads to the hard tissue around the implant. If left untreated, it can lead to decreased bone density and loss of the implant. Therefore, it is crucial to improve the antibacterial and biological activity of implants to achieve dual functions. In this study, we prepared a Ce-doped TiO2 coating on the surface of pure titanium by micro-arc oxidation (MAO) for the prevention of peri-implantitis. We systematically investigated the physicochemical properties, antibacterial activity, and biocompatibility of Ce-doped coatings in vitro and in vivo. The results demonstrated that the increase of Ce concentration in the coating could increase the proliferation, adhesion and osteogenic differentiation of BMSCs in vitro. Results from in vivo osteogenesis experiments demonstrated that the 2Ce-MAO coating exhibited superior efficacy in promoting implant repair in osteoporotic rats. Furthermore, the results of in vitro and in vivo antibacterial experiments indicated that the Ce-TiO2 coating exhibits excellent antibacterial and anti-inflammatory properties. These findings suggest that the Ce-TiO2 coating prepared via MAO may be a promising approach for preventing peri-implantitis and promoting osteogenesis in osteoporosis.http://www.sciencedirect.com/science/article/pii/S026412752300727XCe dopedOsteogenic differentiationAntibacterialMicro-arc oxidation |
| spellingShingle | Shengcai Qi Binbin Kang Chao Yao Dongmei Lan Xiaohong Chen Fengcang Ma Ping Liu Yuehua Liu Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation Materials & Design Ce doped Osteogenic differentiation Antibacterial Micro-arc oxidation |
| title | Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation |
| title_full | Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation |
| title_fullStr | Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation |
| title_full_unstemmed | Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation |
| title_short | Cerium doped TiO2 coating with superior antibacterial property and biocompatibility prepared by micro-arc oxidation |
| title_sort | cerium doped tio2 coating with superior antibacterial property and biocompatibility prepared by micro arc oxidation |
| topic | Ce doped Osteogenic differentiation Antibacterial Micro-arc oxidation |
| url | http://www.sciencedirect.com/science/article/pii/S026412752300727X |
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