Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine

Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine

Gemcitabine and erlotinib are the chemotherapeutic agents used in the treatment of various cancers and their combination is being accepted as a first-line treatment of advanced pancreatic cancer. Hyangsayukgunja-tang (HYT) is a traditional oriental medicine used in various digestive disorders and po...

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Bibliographic Details
Main Authors: Tae Hwan Kim, Soyoung Shin, Sarah Kim, Jürgen B. Bulitta, Kwon-Yeon Weon, Sang Hoon Joo, Eunsook Ma, Sun Dong Yoo, Gi-Young Park, Dong Rak Kwon, Seok Won Jeong, Da Young Lee, Beom Soo Shin
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
herbal medicine
drug-drug interaction
pharmacokinetics
gemcitabine
erlotinib
Hyangsayukgunja-tang
population pharmacokinetic modeling
Online Access:https://www.mdpi.com/1420-3049/22/9/1515

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