Resolution of Inflammation in Retinal Disorders: Briefly the State
The most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss. Resolution of inflammation is emerging as a critical phas...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/9/4501 |
| _version_ | 1797504730011795456 |
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| author | Maria Consiglia Trotta Carlo Gesualdo Francesco Petrillo Caterina Claudia Lepre Alberto Della Corte Giancuomo Cavasso Giulia Maggiore Anca Hermenean Francesca Simonelli Michele D’Amico Settimio Rossi |
| author_facet | Maria Consiglia Trotta Carlo Gesualdo Francesco Petrillo Caterina Claudia Lepre Alberto Della Corte Giancuomo Cavasso Giulia Maggiore Anca Hermenean Francesca Simonelli Michele D’Amico Settimio Rossi |
| author_sort | Maria Consiglia Trotta |
| collection | DOAJ |
| description | The most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss. Resolution of inflammation is emerging as a critical phase able to counteract the inflammatory process leading to the progression of retinal damage. Particularly, pro-resolving mediators (PMs) play a key role in the modulation of inflammatory exudates and could be considered a new target to be investigated in different inflammatory-autoimmune pathologies. Here, we highlight the most recent studies concerning the role of the main PMs (lipoxins, resolvins, prtectins, maresins and annexins) in retinal inflammation, in order to collect the best evidence in the field of inflammatory retinal damage resolution and to propose novel pharmacological approaches in the management of the most common retinal diseases. |
| first_indexed | 2024-03-10T04:08:29Z |
| format | Article |
| id | doaj.art-b644286dae1b4383809eb3a154c0e0ed |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:08:29Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b644286dae1b4383809eb3a154c0e0ed2023-11-23T08:18:05ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01239450110.3390/ijms23094501Resolution of Inflammation in Retinal Disorders: Briefly the StateMaria Consiglia Trotta0Carlo Gesualdo1Francesco Petrillo2Caterina Claudia Lepre3Alberto Della Corte4Giancuomo Cavasso5Giulia Maggiore6Anca Hermenean7Francesca Simonelli8Michele D’Amico9Settimio Rossi10Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli 16, 80138 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 6, 80131 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli 16, 80138 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli 16, 80138 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 6, 80131 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 6, 80131 Naples, ItalyDepartment of Ophthalmology, University of Foggia, Viale Luigi Pinto 1, 71122 Foggia, Italy“Aurel Ardelean” Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Revolutiei Av., 310414 Arad, RomaniaEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 6, 80131 Naples, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli 16, 80138 Naples, ItalyEye Clinic, Multidisciplinary Department of Medical, Surgical and Dental Sciences, University of Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 6, 80131 Naples, ItalyThe most frequent retinal diseases, such as diabetic retinopathy, age-related macular degeneration and posterior uveitis, are underlined by oxidative stress or aging-induced retinal inflammation, which contributes to vision impairing or loss. Resolution of inflammation is emerging as a critical phase able to counteract the inflammatory process leading to the progression of retinal damage. Particularly, pro-resolving mediators (PMs) play a key role in the modulation of inflammatory exudates and could be considered a new target to be investigated in different inflammatory-autoimmune pathologies. Here, we highlight the most recent studies concerning the role of the main PMs (lipoxins, resolvins, prtectins, maresins and annexins) in retinal inflammation, in order to collect the best evidence in the field of inflammatory retinal damage resolution and to propose novel pharmacological approaches in the management of the most common retinal diseases.https://www.mdpi.com/1422-0067/23/9/4501retinopathyinflammationpro-resolving mediatorslipoxinsresolvinsprotectins |
| spellingShingle | Maria Consiglia Trotta Carlo Gesualdo Francesco Petrillo Caterina Claudia Lepre Alberto Della Corte Giancuomo Cavasso Giulia Maggiore Anca Hermenean Francesca Simonelli Michele D’Amico Settimio Rossi Resolution of Inflammation in Retinal Disorders: Briefly the State International Journal of Molecular Sciences retinopathy inflammation pro-resolving mediators lipoxins resolvins protectins |
| title | Resolution of Inflammation in Retinal Disorders: Briefly the State |
| title_full | Resolution of Inflammation in Retinal Disorders: Briefly the State |
| title_fullStr | Resolution of Inflammation in Retinal Disorders: Briefly the State |
| title_full_unstemmed | Resolution of Inflammation in Retinal Disorders: Briefly the State |
| title_short | Resolution of Inflammation in Retinal Disorders: Briefly the State |
| title_sort | resolution of inflammation in retinal disorders briefly the state |
| topic | retinopathy inflammation pro-resolving mediators lipoxins resolvins protectins |
| url | https://www.mdpi.com/1422-0067/23/9/4501 |
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