Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction
BackgroundThe occurrence of new-onset atrial fibrillation (NOAF) post-acute myocardial infarction (AMI) is associated with worse outcomes. In this study, we sought to assess the predictive effect of stress hyperglycemia ratio (SHR) and neutrophil to lymphocyte ratio (NLR) to predict NOAF in patients...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1051078/full |
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| author | Lifei Pan Zhitong Li Chenglin Li Xiaopeng Dong Tesfaldet H. Hidru Fei Liu Yunlong Xia Xiaolei Yang Lei Zhong Ying Liu |
| author_facet | Lifei Pan Zhitong Li Chenglin Li Xiaopeng Dong Tesfaldet H. Hidru Fei Liu Yunlong Xia Xiaolei Yang Lei Zhong Ying Liu |
| author_sort | Lifei Pan |
| collection | DOAJ |
| description | BackgroundThe occurrence of new-onset atrial fibrillation (NOAF) post-acute myocardial infarction (AMI) is associated with worse outcomes. In this study, we sought to assess the predictive effect of stress hyperglycemia ratio (SHR) and neutrophil to lymphocyte ratio (NLR) to predict NOAF in patients with AMI.Materials and methodsWe recruited 3,194 individuals with AMI but free of atrial fibrillation (AF). AMI cases were stratified into groups according to SHR and NLR quartiles and were further categorized based on diabetes status. High SHR and high NLR were defined as the highest quartile of SHR and NLR. A nomogram incorporating risk factors for NOAF was constructed using multivariate logistic regression analyses. The performance of the novel nomogram was tested for predictive performance, agreement between the actual and predicted probability, and clinical utility using area under the curve (AUC), bootstrapped calibration curves, and decision curve analysis, respectively.ResultA total of 245 (7.67%) patients developed NOAF post-AMI. The NOAF cases had higher values of SHR and NLR than non-NOAF patients after AMI regardless of diabetes status. After adjusting for potential confounders, high SHR and NLR were independently associated with NOAF post-AMI. Moreover, the novel nomogram incorporating high NLR and high SHR for NOAF risk estimation in patients with AMI showed satisfactory performance assessed by the AUC, calibration curves, decision curve analysis.ConclusionSHR and NLR were independently associated with NOAF in AMI patients. The constructed novel nomogram that incorporates SHR and NLR might assist in NOAF risk stratification post-AMI. |
| first_indexed | 2024-04-12T10:42:53Z |
| format | Article |
| id | doaj.art-b64608d61db64040b0ebc3e92d3e0691 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T10:42:53Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-b64608d61db64040b0ebc3e92d3e06912022-12-22T03:36:33ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10510781051078Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarctionLifei PanZhitong LiChenglin LiXiaopeng DongTesfaldet H. HidruFei LiuYunlong XiaXiaolei YangLei ZhongYing LiuBackgroundThe occurrence of new-onset atrial fibrillation (NOAF) post-acute myocardial infarction (AMI) is associated with worse outcomes. In this study, we sought to assess the predictive effect of stress hyperglycemia ratio (SHR) and neutrophil to lymphocyte ratio (NLR) to predict NOAF in patients with AMI.Materials and methodsWe recruited 3,194 individuals with AMI but free of atrial fibrillation (AF). AMI cases were stratified into groups according to SHR and NLR quartiles and were further categorized based on diabetes status. High SHR and high NLR were defined as the highest quartile of SHR and NLR. A nomogram incorporating risk factors for NOAF was constructed using multivariate logistic regression analyses. The performance of the novel nomogram was tested for predictive performance, agreement between the actual and predicted probability, and clinical utility using area under the curve (AUC), bootstrapped calibration curves, and decision curve analysis, respectively.ResultA total of 245 (7.67%) patients developed NOAF post-AMI. The NOAF cases had higher values of SHR and NLR than non-NOAF patients after AMI regardless of diabetes status. After adjusting for potential confounders, high SHR and NLR were independently associated with NOAF post-AMI. Moreover, the novel nomogram incorporating high NLR and high SHR for NOAF risk estimation in patients with AMI showed satisfactory performance assessed by the AUC, calibration curves, decision curve analysis.ConclusionSHR and NLR were independently associated with NOAF in AMI patients. The constructed novel nomogram that incorporates SHR and NLR might assist in NOAF risk stratification post-AMI.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1051078/fullstress hyperglycemia rationeutrophil to lymphocyte ratioacute myocardial infarctionatrial fibrillationdiabetes mellitus |
| spellingShingle | Lifei Pan Zhitong Li Chenglin Li Xiaopeng Dong Tesfaldet H. Hidru Fei Liu Yunlong Xia Xiaolei Yang Lei Zhong Ying Liu Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction Frontiers in Cardiovascular Medicine stress hyperglycemia ratio neutrophil to lymphocyte ratio acute myocardial infarction atrial fibrillation diabetes mellitus |
| title | Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction |
| title_full | Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction |
| title_fullStr | Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction |
| title_full_unstemmed | Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction |
| title_short | Stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new-onset atrial fibrillation in patients with acute myocardial infarction |
| title_sort | stress hyperglycemia ratio and neutrophil to lymphocyte ratio are reliable predictors of new onset atrial fibrillation in patients with acute myocardial infarction |
| topic | stress hyperglycemia ratio neutrophil to lymphocyte ratio acute myocardial infarction atrial fibrillation diabetes mellitus |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1051078/full |
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