Brain imaging correlates of self- and other-reflection in schizophrenia
Background: An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been prop...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158219304759 |
| _version_ | 1811268539546337280 |
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| author | Paola Fuentes-Claramonte Marta Martin-Subero Pilar Salgado-Pineda Aniol Santo-Angles Isabel Argila-Plaza Josep Salavert Antoni Arévalo Clara Bosque Carmen Sarri Amalia Guerrero-Pedraza Antoni Capdevila Salvador Sarró Peter J. McKenna Edith Pomarol-Clotet Raymond Salvador |
| author_facet | Paola Fuentes-Claramonte Marta Martin-Subero Pilar Salgado-Pineda Aniol Santo-Angles Isabel Argila-Plaza Josep Salavert Antoni Arévalo Clara Bosque Carmen Sarri Amalia Guerrero-Pedraza Antoni Capdevila Salvador Sarró Peter J. McKenna Edith Pomarol-Clotet Raymond Salvador |
| author_sort | Paola Fuentes-Claramonte |
| collection | DOAJ |
| description | Background: An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results. Methods: Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing. Results: Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity. Conclusions: Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group. Keywords: Psychosis, Schizophrenia, Self-reflection, Other-reflection, fMRI, Temporo-parietal junction |
| first_indexed | 2024-04-12T21:24:54Z |
| format | Article |
| id | doaj.art-b646107adc8d47ff8dc28d1360b873d6 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T21:24:54Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-b646107adc8d47ff8dc28d1360b873d62022-12-22T03:16:12ZengElsevierNeuroImage: Clinical2213-15822020-01-0125Brain imaging correlates of self- and other-reflection in schizophreniaPaola Fuentes-Claramonte0Marta Martin-Subero1Pilar Salgado-Pineda2Aniol Santo-Angles3Isabel Argila-Plaza4Josep Salavert5Antoni Arévalo6Clara Bosque7Carmen Sarri8Amalia Guerrero-Pedraza9Antoni Capdevila10Salvador Sarró11Peter J. McKenna12Edith Pomarol-Clotet13Raymond Salvador14FIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona SpainDepartment of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Psychiatry Department, Hospital Sant Rafael, Barcelona, SpainPsychiatry Department, Hospital Sagrat Cor Martorell Barcelona, SpainBenito Menni Centre Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain.Benito Menni Centre Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain.Benito Menni Centre Assistencial en Salut Mental, Sant Boi de Llobregat, Barcelona, Spain.Radiology Unit, Hospital de la Santa Creu i Sant Pau (HSCSP), Barcelona, Spain; CIBER-BBN (Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainFIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Spain; Corresponding author at: FIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain.FIDMAG Germanes Hospitalàries Research Foundation, Carrer Dr. Antoni Pujadas, 38, 08830 Sant Boi de Llobregat, Barcelona Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), SpainBackground: An alteration in self/other differentiation has been proposed as a basis for several symptoms in schizophrenia, including delusions of reference and social functioning deficits. Dysfunction of the right temporo-parietal junction (TPJ), a region linked with social cognition, has been proposed as the basis of this alteration. However, imaging studies of self- and other-processing in schizophrenia have shown, so far, inconsistent results. Methods: Patients with schizophrenia and healthy controls underwent fMRI scanning while performing a task with three conditions: self-reflection, other-reflection and semantic processing. Results: Both groups activated similar brain regions for self- and other-reflection compared to semantic processing, including the medial prefrontal cortex, the precuneus and the TPJ. Compared to healthy subjects, patients hyperactivated the left lateral frontal cortex during self- and other-reflection. In other-reflection, compared to self-reflection, patients failed to increase right TPJ activity. Conclusions: Altered activity in the right TPJ supports a disturbance in self/other differentiation in schizophrenia, which could be linked with psychotic symptoms and affect social functioning in patients. Hyperactivity of the lateral frontal cortex for self- and other-reflection suggests the presence of greater cognitive demand to perform the task in the patient group. Keywords: Psychosis, Schizophrenia, Self-reflection, Other-reflection, fMRI, Temporo-parietal junctionhttp://www.sciencedirect.com/science/article/pii/S2213158219304759 |
| spellingShingle | Paola Fuentes-Claramonte Marta Martin-Subero Pilar Salgado-Pineda Aniol Santo-Angles Isabel Argila-Plaza Josep Salavert Antoni Arévalo Clara Bosque Carmen Sarri Amalia Guerrero-Pedraza Antoni Capdevila Salvador Sarró Peter J. McKenna Edith Pomarol-Clotet Raymond Salvador Brain imaging correlates of self- and other-reflection in schizophrenia NeuroImage: Clinical |
| title | Brain imaging correlates of self- and other-reflection in schizophrenia |
| title_full | Brain imaging correlates of self- and other-reflection in schizophrenia |
| title_fullStr | Brain imaging correlates of self- and other-reflection in schizophrenia |
| title_full_unstemmed | Brain imaging correlates of self- and other-reflection in schizophrenia |
| title_short | Brain imaging correlates of self- and other-reflection in schizophrenia |
| title_sort | brain imaging correlates of self and other reflection in schizophrenia |
| url | http://www.sciencedirect.com/science/article/pii/S2213158219304759 |
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