Parallel Changes in Mood and Melatonin Rhythm Following an Adjunctive Multimodal Chronobiological Intervention With Agomelatine in People With Depression: A Proof of Concept Open Label Study

Parallel Changes in Mood and Melatonin Rhythm Following an Adjunctive Multimodal Chronobiological Intervention With Agomelatine in People With Depression: A Proof of Concept Open Label Study

Background: Agomelatine is a melatonin agonist and 5HT antagonist developed for the treatment of major depressive disorder which also has some effects on the circadian system. Since circadian dysfunctions are thought to play a role in the pathophysiology of depression, some of the mechanism of actio...

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Bibliographic Details
Main Authors: Rebecca Robillard, Joanne S. Carpenter, Kristy-Lee Feilds, Daniel F. Hermens, Django White, Sharon L. Naismith, Delwyn Bartlett, Bradley Whitwell, James Southan, Elizabeth M. Scott, Ian B. Hickie
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Psychiatry
Subjects:
melatonin agonist
agomelatine
melatonin
depression
circadian rhythms dysfunctions
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00624/full

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