Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors
BackgroundTumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1006183/full |
| _version_ | 1797895162010009600 |
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| author | Zigao Huang Baojia Li Haiquan Qin Xianwei Mo |
| author_facet | Zigao Huang Baojia Li Haiquan Qin Xianwei Mo |
| author_sort | Zigao Huang |
| collection | DOAJ |
| description | BackgroundTumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with gastrointestinal cancer with KTs.MethodsThe infiltration of various types of TAMs was detected in surgical tissues of 35 patients with KTs using immunohistochemical staining. The level of infiltration of TAMs in tumor nests (TN), tumor stroma (TS), and invasive margin (IM) areas was evaluated. The Kaplan–Meier method and univariate/multivariate Cox regression risk models were used to analyze the relationship between the degree of TAMs invasion and overall survival (OS) and progression-free survival (PFS).ResultsThe distribution of TAMs exhibited spatial heterogeneity between TN, TS, and IM regions in primary tumor (PT) and KT tissues. TAMs infiltrated in the TN had greater prognostic value and were barely influenced by preoperative neoadjuvant therapy, despite similar grades of invasion in PT and KT tissues. Moreover, the number of CD68+ TAMs in TN of KT tissues was an independent risk factor affecting patient OS, whereas tumor resection scope might be an independent risk factor affecting patient PFS.ConclusionsIn view of the close relationship between TAMs, the tumor microenvironment and patient prognosis, targeting TAMs combined with chemotherapy is expected to become a new approach for the treatment of patients with KTs. |
| first_indexed | 2024-04-10T07:21:05Z |
| format | Article |
| id | doaj.art-b646e99e814249008f1c214069717e4d |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T07:21:05Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b646e99e814249008f1c214069717e4d2023-02-24T11:45:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10061831006183Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumorsZigao HuangBaojia LiHaiquan QinXianwei MoBackgroundTumor-associated macrophages (TAMs) have been used as potential drug targets in preclinical research and clinical trials of various cancers. However, their distribution in Krukenberg tumors (KTs) remains unclear. We investigated the expression and prognostic value of TAMs in patients with gastrointestinal cancer with KTs.MethodsThe infiltration of various types of TAMs was detected in surgical tissues of 35 patients with KTs using immunohistochemical staining. The level of infiltration of TAMs in tumor nests (TN), tumor stroma (TS), and invasive margin (IM) areas was evaluated. The Kaplan–Meier method and univariate/multivariate Cox regression risk models were used to analyze the relationship between the degree of TAMs invasion and overall survival (OS) and progression-free survival (PFS).ResultsThe distribution of TAMs exhibited spatial heterogeneity between TN, TS, and IM regions in primary tumor (PT) and KT tissues. TAMs infiltrated in the TN had greater prognostic value and were barely influenced by preoperative neoadjuvant therapy, despite similar grades of invasion in PT and KT tissues. Moreover, the number of CD68+ TAMs in TN of KT tissues was an independent risk factor affecting patient OS, whereas tumor resection scope might be an independent risk factor affecting patient PFS.ConclusionsIn view of the close relationship between TAMs, the tumor microenvironment and patient prognosis, targeting TAMs combined with chemotherapy is expected to become a new approach for the treatment of patients with KTs.https://www.frontiersin.org/articles/10.3389/fonc.2023.1006183/fullKrukenberg tumortumor-associated macrophageprognosisimmunohistochemistrygastrointestinal cancer |
| spellingShingle | Zigao Huang Baojia Li Haiquan Qin Xianwei Mo Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors Frontiers in Oncology Krukenberg tumor tumor-associated macrophage prognosis immunohistochemistry gastrointestinal cancer |
| title | Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors |
| title_full | Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors |
| title_fullStr | Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors |
| title_full_unstemmed | Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors |
| title_short | Invasion characteristics and clinical significance of tumor-associated macrophages in gastrointestinal Krukenberg tumors |
| title_sort | invasion characteristics and clinical significance of tumor associated macrophages in gastrointestinal krukenberg tumors |
| topic | Krukenberg tumor tumor-associated macrophage prognosis immunohistochemistry gastrointestinal cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1006183/full |
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