Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas
Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-04398-2 |
| _version_ | 1797958592354058240 |
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| author | Nirmal Verma Gopal Viswanathan Velmurugan Edric Winford Han Coburn Deepak Kotiya Noah Leibold Laura Radulescu Sanda Despa Kuey C. Chen Linda J. Van Eldik Peter T. Nelson Donna M. Wilcock Gregory A. Jicha Ann M. Stowe Larry B. Goldstein David K. Powel Jeffrey H. Walton Manuel F. Navedo Matthew A. Nystoriak Andrew J. Murray Geert Jan Biessels Claire Troakes Henrik Zetterberg John Hardy Tammaryn Lashley Florin Despa |
| author_facet | Nirmal Verma Gopal Viswanathan Velmurugan Edric Winford Han Coburn Deepak Kotiya Noah Leibold Laura Radulescu Sanda Despa Kuey C. Chen Linda J. Van Eldik Peter T. Nelson Donna M. Wilcock Gregory A. Jicha Ann M. Stowe Larry B. Goldstein David K. Powel Jeffrey H. Walton Manuel F. Navedo Matthew A. Nystoriak Andrew J. Murray Geert Jan Biessels Claire Troakes Henrik Zetterberg John Hardy Tammaryn Lashley Florin Despa |
| author_sort | Nirmal Verma |
| collection | DOAJ |
| description | Converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains. |
| first_indexed | 2024-04-11T00:21:02Z |
| format | Article |
| id | doaj.art-b6483589f28142ef83c37fe4a6e6a7dc |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-11T00:21:02Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-b6483589f28142ef83c37fe4a6e6a7dc2023-01-08T12:18:37ZengNature PortfolioCommunications Biology2399-36422023-01-016111610.1038/s42003-022-04398-2Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreasNirmal Verma0Gopal Viswanathan Velmurugan1Edric Winford2Han Coburn3Deepak Kotiya4Noah Leibold5Laura Radulescu6Sanda Despa7Kuey C. Chen8Linda J. Van Eldik9Peter T. Nelson10Donna M. Wilcock11Gregory A. Jicha12Ann M. Stowe13Larry B. Goldstein14David K. Powel15Jeffrey H. Walton16Manuel F. Navedo17Matthew A. Nystoriak18Andrew J. Murray19Geert Jan Biessels20Claire Troakes21Henrik Zetterberg22John Hardy23Tammaryn Lashley24Florin Despa25Department of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckyDepartment of Pharmacology and Nutritional Sciences, University of KentuckySanders-Brown Center on Aging, University of KentuckySanders-Brown Center on Aging, University of KentuckySanders-Brown Center on Aging, University of KentuckySanders-Brown Center on Aging, University of KentuckyDepartment of Neurology, University of KentuckyDepartment of Neurology, University of KentuckyMagnetic Resonance Imaging and Spectroscopy Center, University of KentuckyNMR Facility, University of CaliforniaDepartment of Pharmacology, University of CaliforniaDepartment of Medicine, University of LouisvilleDepartment of Physiology, Development and Neuroscience, University of CambridgeDepartment of Neurology, University Medical Center UtrechtBasic and Clinical Neuroscience Department, King’s College LondonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of GothenburgDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen SquareDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, Queen SquareDepartment of Pharmacology and Nutritional Sciences, University of KentuckyConverging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and Aβ pathology in Alzheimer’s disease brains.https://doi.org/10.1038/s42003-022-04398-2 |
| spellingShingle | Nirmal Verma Gopal Viswanathan Velmurugan Edric Winford Han Coburn Deepak Kotiya Noah Leibold Laura Radulescu Sanda Despa Kuey C. Chen Linda J. Van Eldik Peter T. Nelson Donna M. Wilcock Gregory A. Jicha Ann M. Stowe Larry B. Goldstein David K. Powel Jeffrey H. Walton Manuel F. Navedo Matthew A. Nystoriak Andrew J. Murray Geert Jan Biessels Claire Troakes Henrik Zetterberg John Hardy Tammaryn Lashley Florin Despa Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas Communications Biology |
| title | Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
| title_full | Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
| title_fullStr | Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
| title_full_unstemmed | Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
| title_short | Aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
| title_sort | aβ efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid forming amylin secreted from pancreas |
| url | https://doi.org/10.1038/s42003-022-04398-2 |
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