Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals
To identify the malignancy in human breast, hand-held optical probes are simulated using the Monte Carlo method. These devices were used to scan different tissue equivalent numerical breast phantoms to detect the embedded cancerous tissues in them. The phantoms were simulated with glandular tissues...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Results in Optics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666950123000627 |
| _version_ | 1797846375146192896 |
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| author | Jim Elliot Christopherjames D. Devakumar J.B. Jeeva Megha Singh |
| author_facet | Jim Elliot Christopherjames D. Devakumar J.B. Jeeva Megha Singh |
| author_sort | Jim Elliot Christopherjames |
| collection | DOAJ |
| description | To identify the malignancy in human breast, hand-held optical probes are simulated using the Monte Carlo method. These devices were used to scan different tissue equivalent numerical breast phantoms to detect the embedded cancerous tissues in them. The phantoms were simulated with glandular tissues embedded with ductal carcinoma of size 5 mm and 2 mm diameter at various depths. Two optical probes namely dual side detector (DSD) probe and a single side detector (SSD) probe are designed through which one million light photons of wavelengths 600 nm and 800 nm respectively were passed into the numerical phantoms. The photons that were backscattered from the phantoms were received by the detectors in both probes. They were measured as signals and both probes were able to detect the presence of the embedded cancerous tissues at different depths. The results indicate that the probes with a light source at 800 nm could detect deep-seated inhomogeneities. The absolute value of Peak Intensity (|PI|) and Full Width at Half Maximum (FWHM) would be indicative of their location and approximate size of the embedded tissues. The |PI| decreases with the size and depth of the embedded tissue, and the FWHM increases with depth. The results show that the designed probes are capable of detecting small variations in tissues. |
| first_indexed | 2024-04-09T17:53:56Z |
| format | Article |
| id | doaj.art-b648361ea1c941fbabb7b9c6dcc5c7a8 |
| institution | Directory Open Access Journal |
| issn | 2666-9501 |
| language | English |
| last_indexed | 2024-04-09T17:53:56Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Optics |
| spelling | doaj.art-b648361ea1c941fbabb7b9c6dcc5c7a82023-04-15T05:55:23ZengElsevierResults in Optics2666-95012023-05-0111100410Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signalsJim Elliot Christopherjames0D. Devakumar1J.B. Jeeva2Megha Singh3Department of Biomedical Engineering, Saveetha Engineering College, Saveetha Nagar, Thandalam, Chennai 602105, India; Department of Sensor and Biomedical Technology, School of Electronics Engineering, Vellore Institute of Technology, Vellore 632014, IndiaDepartment of Nuclear Medicine, Christian Medical College, Vellore 632004, IndiaDepartment of Sensor and Biomedical Technology, School of Electronics Engineering, Vellore Institute of Technology, Vellore 632014, India; Corresponding author.Department of Sensor and Biomedical Technology, School of Electronics Engineering, Vellore Institute of Technology, Vellore 632014, India; Center for Biomedical Engineering, S.G.N.E Foundation, 3rd St. Park Avenue, Chennai 600042, IndiaTo identify the malignancy in human breast, hand-held optical probes are simulated using the Monte Carlo method. These devices were used to scan different tissue equivalent numerical breast phantoms to detect the embedded cancerous tissues in them. The phantoms were simulated with glandular tissues embedded with ductal carcinoma of size 5 mm and 2 mm diameter at various depths. Two optical probes namely dual side detector (DSD) probe and a single side detector (SSD) probe are designed through which one million light photons of wavelengths 600 nm and 800 nm respectively were passed into the numerical phantoms. The photons that were backscattered from the phantoms were received by the detectors in both probes. They were measured as signals and both probes were able to detect the presence of the embedded cancerous tissues at different depths. The results indicate that the probes with a light source at 800 nm could detect deep-seated inhomogeneities. The absolute value of Peak Intensity (|PI|) and Full Width at Half Maximum (FWHM) would be indicative of their location and approximate size of the embedded tissues. The |PI| decreases with the size and depth of the embedded tissue, and the FWHM increases with depth. The results show that the designed probes are capable of detecting small variations in tissues.http://www.sciencedirect.com/science/article/pii/S2666950123000627Monte Carlo simulationHand-held optical probesBreast cancer detectionDiffuse reflectanceNon-invasive ductal carcinoma |
| spellingShingle | Jim Elliot Christopherjames D. Devakumar J.B. Jeeva Megha Singh Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals Results in Optics Monte Carlo simulation Hand-held optical probes Breast cancer detection Diffuse reflectance Non-invasive ductal carcinoma |
| title | Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals |
| title_full | Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals |
| title_fullStr | Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals |
| title_full_unstemmed | Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals |
| title_short | Monte Carlo simulation of handheld probes to detect non-invasive ductal carcinoma from diffuse optical reflectance signals |
| title_sort | monte carlo simulation of handheld probes to detect non invasive ductal carcinoma from diffuse optical reflectance signals |
| topic | Monte Carlo simulation Hand-held optical probes Breast cancer detection Diffuse reflectance Non-invasive ductal carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S2666950123000627 |
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