Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery
Background: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery.Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vasculari...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126269/full |
| _version_ | 1797821448082948096 |
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| author | Guanmin Li Guanmin Li Chen Lei Chen Lei Xiuying Shan Xiuying Shan Xuejun Ni Xuejun Ni Guojie Chen Meishui Wang Meishui Wang Ruonan Ke Ruonan Ke Biao Wang Biao Wang |
| author_facet | Guanmin Li Guanmin Li Chen Lei Chen Lei Xiuying Shan Xiuying Shan Xuejun Ni Xuejun Ni Guojie Chen Meishui Wang Meishui Wang Ruonan Ke Ruonan Ke Biao Wang Biao Wang |
| author_sort | Guanmin Li |
| collection | DOAJ |
| description | Background: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery.Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascularization of the newly born tissue compound were analyzed and evaluated by tissue staining and Micro-CT scanning.Results: The neoplastic fibrous tissue formed in the vascularized tissue engineering chamber with the introduction of abdominal superficial vessels, similar to normal fascia, was superior to the control group in terms of vascularization, vascular density, total vascular volume, and total vascular volume/total tissue volume.Conclusion:In vivo, introducing abdominal superficial vessels in the tissue engineering chamber prepped for ear prosthesis may form a well-vascularized pedicled fascia-prosthesis compound that can be used for ear reconstruction. |
| first_indexed | 2024-03-13T09:52:50Z |
| format | Article |
| id | doaj.art-b6485371f9e74f88bcf274c5a5d035a7 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-13T09:52:50Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-b6485371f9e74f88bcf274c5a5d035a72023-05-24T05:47:15ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-05-011110.3389/fbioe.2023.11262691126269Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgeryGuanmin Li0Guanmin Li1Chen Lei2Chen Lei3Xiuying Shan4Xiuying Shan5Xuejun Ni6Xuejun Ni7Guojie Chen8Meishui Wang9Meishui Wang10Ruonan Ke11Ruonan Ke12Biao Wang13Biao Wang14Department of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaSenior Department of Burns and Plastic Surgery, The Fourth Medical Center of Chinese PLA General Hospital, Beijing, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaDepartment of Plastic and Wound Repair Surgery, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaBackground: To design a vascular pedicled fascia-prosthesis compound model that can be used for ear reconstruction surgery.Methods: A vascularized tissue engineering chamber model was constructed in New Zealand rabbits, and fresh tissues were obtained after 4 weeks. The histomorphology and vascularization of the newly born tissue compound were analyzed and evaluated by tissue staining and Micro-CT scanning.Results: The neoplastic fibrous tissue formed in the vascularized tissue engineering chamber with the introduction of abdominal superficial vessels, similar to normal fascia, was superior to the control group in terms of vascularization, vascular density, total vascular volume, and total vascular volume/total tissue volume.Conclusion:In vivo, introducing abdominal superficial vessels in the tissue engineering chamber prepped for ear prosthesis may form a well-vascularized pedicled fascia-prosthesis compound that can be used for ear reconstruction.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126269/fullear reconstructionvascularized tissue engineering chamberpedicled fascial flapear prosthesisabdominal superficial vessels |
| spellingShingle | Guanmin Li Guanmin Li Chen Lei Chen Lei Xiuying Shan Xiuying Shan Xuejun Ni Xuejun Ni Guojie Chen Meishui Wang Meishui Wang Ruonan Ke Ruonan Ke Biao Wang Biao Wang Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery Frontiers in Bioengineering and Biotechnology ear reconstruction vascularized tissue engineering chamber pedicled fascial flap ear prosthesis abdominal superficial vessels |
| title | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
| title_full | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
| title_fullStr | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
| title_full_unstemmed | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
| title_short | Construction of a vascularized fascia-prosthesis compound model with axial pedicle for ear reconstruction surgery |
| title_sort | construction of a vascularized fascia prosthesis compound model with axial pedicle for ear reconstruction surgery |
| topic | ear reconstruction vascularized tissue engineering chamber pedicled fascial flap ear prosthesis abdominal superficial vessels |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1126269/full |
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