Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

Primary cilia and SHH signaling impairments in human and mouse models of Parkinson’s disease

Here, the authors reveal using single-cell RNA sequencing that Parkinson’s disease (PD) patient-derived neuronal cells show altered primary cilia morphology and signaling suggesting cilia dysfunction may underlie PD pathogenesis.

Bibliographic Details
Main Authors: Sebastian Schmidt, Malte D. Luecken, Dietrich Trümbach, Sina Hembach, Kristina M. Niedermeier, Nicole Wenck, Klaus Pflügler, Constantin Stautner, Anika Böttcher, Heiko Lickert, Ciro Ramirez-Suastegui, Ruhel Ahmad, Michael J. Ziller, Julia C. Fitzgerald, Viktoria Ruf, Wilma D. J. van de Berg, Allert J. Jonker, Thomas Gasser, Beate Winner, Jürgen Winkler, Daniela M. Vogt Weisenhorn, Florian Giesert, Fabian J. Theis, Wolfgang Wurst
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32229-9

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