Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment
Alzheimer’s disease (AD), which most commonly occurs in the elder, is a chronic neurodegenerative disease with no agreed drugs or treatment protocols at present. Amnestic mild cognitive impairment (aMCI), earlier than AD onset and later than subjective cognitive decline (SCD) onset, has a serious pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2020.00185/full |
| _version_ | 1818921915331379200 |
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| author | Chunting Cai Chenxi Huang Chenhui Yang Xiaodong Zhang Yonghong Peng Wenbing Zhao Xin Hong Fujia Ren Dan Hong Yutian Xiao Jiqiang Yan |
| author_facet | Chunting Cai Chenxi Huang Chenhui Yang Xiaodong Zhang Yonghong Peng Wenbing Zhao Xin Hong Fujia Ren Dan Hong Yutian Xiao Jiqiang Yan |
| author_sort | Chunting Cai |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), which most commonly occurs in the elder, is a chronic neurodegenerative disease with no agreed drugs or treatment protocols at present. Amnestic mild cognitive impairment (aMCI), earlier than AD onset and later than subjective cognitive decline (SCD) onset, has a serious probability of converting into AD. The SCD, which can last for decades, subjectively complains of decline impairment in memory. Distinct altered patterns of default mode network (DMN) subnetworks connected to the whole brain are perceived as prominent hallmarks of the early stages of AD. Nevertheless, the aberrant phase position connectivity (PPC) connected to the whole brain in DMN subnetworks remains unknown. Here, we hypothesized that there exist distinct variations of PPC in DMN subnetworks connected to the whole brain for patients with SCD and aMCI, which might be acted as discriminatory neuroimaging biomarkers. We recruited 27 healthy controls (HC), 20 SCD and 28 aMCI subjects, respectively, to explore aberrant patterns of PPC in DMN subnetworks connected to the whole brain. In anterior DMN (aDMN), SCD group exhibited aberrant PPC in the regions of right superior cerebellum lobule (SCL), right superior frontal gyrus of medial part (SFGMP), and left fusiform gyrus (FG) in comparison of HC group, by contrast, no prominent difference was found in aMCI group. It is important to note that aMCI group showed increased PPC in the right SFGMP in comparison with SCD group. For posterior DMN (pDMN), SCD group showed decreased PPC in the left superior parietal lobule (SPL) and right superior frontal gyrus (SFG) compared to HC group. It is noteworthy that aMCI group showed decreased PPC in the left middle frontal gyrus of orbital part (MFGOP) and right SFG compared to HC group, yet increased PPC was found in the left superior temporal gyrus of temporal pole (STGTP). Additionally, aMCI group exhibited decreased PPC in the left MFGOP compared to SCD group. Collectively, our results have shown that the aberrant regions of PPC observed in DMN are related to cognitive function, and it might also be served as impressible neuroimaging biomarkers for timely intervention before AD occurs. |
| first_indexed | 2024-12-20T01:45:14Z |
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| id | doaj.art-b648a3cd78f4436b9387b51a9fe8ef71 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T01:45:14Z |
| publishDate | 2020-03-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-b648a3cd78f4436b9387b51a9fe8ef712022-12-21T19:57:48ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-03-011410.3389/fnins.2020.00185532057Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive ImpairmentChunting Cai0Chenxi Huang1Chenhui Yang2Xiaodong Zhang3Yonghong Peng4Wenbing Zhao5Xin Hong6Fujia Ren7Dan Hong8Yutian Xiao9Jiqiang Yan10School of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Xiamen University, Xiamen, ChinaDepartment of Computing and Mathematics, Manchester Metropolitan University, Manchester, United KingdomDepartment of Electrical Engineering and Computer Science, Cleveland State University, Cleveland, OH, United StatesSchool of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaSchool of Informatics, Xiamen University, Xiamen, ChinaAlzheimer’s disease (AD), which most commonly occurs in the elder, is a chronic neurodegenerative disease with no agreed drugs or treatment protocols at present. Amnestic mild cognitive impairment (aMCI), earlier than AD onset and later than subjective cognitive decline (SCD) onset, has a serious probability of converting into AD. The SCD, which can last for decades, subjectively complains of decline impairment in memory. Distinct altered patterns of default mode network (DMN) subnetworks connected to the whole brain are perceived as prominent hallmarks of the early stages of AD. Nevertheless, the aberrant phase position connectivity (PPC) connected to the whole brain in DMN subnetworks remains unknown. Here, we hypothesized that there exist distinct variations of PPC in DMN subnetworks connected to the whole brain for patients with SCD and aMCI, which might be acted as discriminatory neuroimaging biomarkers. We recruited 27 healthy controls (HC), 20 SCD and 28 aMCI subjects, respectively, to explore aberrant patterns of PPC in DMN subnetworks connected to the whole brain. In anterior DMN (aDMN), SCD group exhibited aberrant PPC in the regions of right superior cerebellum lobule (SCL), right superior frontal gyrus of medial part (SFGMP), and left fusiform gyrus (FG) in comparison of HC group, by contrast, no prominent difference was found in aMCI group. It is important to note that aMCI group showed increased PPC in the right SFGMP in comparison with SCD group. For posterior DMN (pDMN), SCD group showed decreased PPC in the left superior parietal lobule (SPL) and right superior frontal gyrus (SFG) compared to HC group. It is noteworthy that aMCI group showed decreased PPC in the left middle frontal gyrus of orbital part (MFGOP) and right SFG compared to HC group, yet increased PPC was found in the left superior temporal gyrus of temporal pole (STGTP). Additionally, aMCI group exhibited decreased PPC in the left MFGOP compared to SCD group. Collectively, our results have shown that the aberrant regions of PPC observed in DMN are related to cognitive function, and it might also be served as impressible neuroimaging biomarkers for timely intervention before AD occurs.https://www.frontiersin.org/article/10.3389/fnins.2020.00185/fullsubjective cognitive declineamnestic mild cognitive impairmentdefault mode networkphase position connectivityneuroimaging biomarkers |
| spellingShingle | Chunting Cai Chenxi Huang Chenhui Yang Xiaodong Zhang Yonghong Peng Wenbing Zhao Xin Hong Fujia Ren Dan Hong Yutian Xiao Jiqiang Yan Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment Frontiers in Neuroscience subjective cognitive decline amnestic mild cognitive impairment default mode network phase position connectivity neuroimaging biomarkers |
| title | Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment |
| title_full | Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment |
| title_fullStr | Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment |
| title_full_unstemmed | Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment |
| title_short | Altered Patterns of Phase Position Connectivity in Default Mode Subnetwork of Subjective Cognitive Decline and Amnestic Mild Cognitive Impairment |
| title_sort | altered patterns of phase position connectivity in default mode subnetwork of subjective cognitive decline and amnestic mild cognitive impairment |
| topic | subjective cognitive decline amnestic mild cognitive impairment default mode network phase position connectivity neuroimaging biomarkers |
| url | https://www.frontiersin.org/article/10.3389/fnins.2020.00185/full |
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