Characterisation of Non-Carbapenemase-Producing Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Based on Their Clinical and Molecular Profile in Malaysia

Non-carbapenemase-producing carbapenem-resistant <i>Klebsiella pneumoniae</i> (NC-CRKP) confers carbapenem resistance through a combination of chromosomal mutations and acquired non-carbapenemase resistance mechanisms. In this study, we aimed to evaluate the clinical and molecular profil...

Full description

Bibliographic Details
Main Authors:	Yee Qing Lee, Sasheela Sri La Sri Ponnampalavanar, Chun Wie Chong, Rina Karunakaran, Kumutha Malar Vellasamy, Kartini Abdul Jabar, Zhi Xian Kong, Min Yi Lau, Cindy Shuan Ju Teh
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Series:	Antibiotics
Subjects:	all-cause in-hospital mortality Charlson Comorbidity Index (CCI) efflux pump non-carbapenemase-producing carbapenem-resistant <i>Klebsiella pneumoniae</i> porin loss resistance genes
Online Access:	https://www.mdpi.com/2079-6382/11/11/1670

Similar Items

A retrospective study on molecular epidemiology trends of carbapenem resistant Enterobacteriaceae in a teaching hospital in Malaysia
by: Zhi Xian Kong, et al.
Published: (2022-02-01)

Molecular Characterization of Carbapenem Resistant <i>Klebsiella pneumoniae</i> in Malaysia Hospital
by: Min Yi Lau, et al.
Published: (2021-03-01)

Molecular Characterization of Carbapenem-Resistant <i>Acinetobacter baumannii</i> Isolated from the Intensive Care Unit in a Tertiary Teaching Hospital in Malaysia
by: Jia Jie Woon, et al.
Published: (2021-11-01)

Resistance to Carbapenems in Non-Typhoidal Salmonella enterica Serovars from Humans, Animals and Food
by: Javier Fernández, et al.
Published: (2018-04-01)

The Antimicrobial Resistance Characteristics of Imipenem-Non-Susceptible, Imipenemase-6-Producing <i>Escherichia coli</i>
by: Reo Onishi, et al.
Published: (2021-12-01)

A Review of Carbapenem Resistance in <i>Enterobacterales</i> and Its Detection Techniques
by: Oznur Caliskan-Aydogan, et al.
Published: (2023-06-01)

High-Level Carbapenem Resistance among OXA-48-Producing <i>Klebsiella</i><i>pneumoniae</i> with Functional OmpK36 Alterations: Maintenance of Ceftazidime/Avibactam Susceptibility
by: Pilar Lumbreras-Iglesias, et al.
Published: (2021-09-01)

Improved Phenotype-Based Definition for Identifying Carbapenemase Producers among Carbapenem-Resistant Enterobacteriaceae
by: Nora Chea, et al.
Published: (2015-09-01)

The evolutionary mechanism of non-carbapenemase carbapenem-resistant phenotypes in Klebsiella spp
by: Natalia C Rosas, et al.
Published: (2023-07-01)

Disinfection Strategies for Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in a Healthcare Facility
by: Lijia Ni, et al.
Published: (2022-05-01)

The Predominance of <i>Klebsiella aerogenes</i> among Carbapenem-Resistant <i>Enterobacteriaceae</i> Infections in Japan
by: Kosuke Kamio, et al.
Published: (2022-06-01)

Clinical and molecular characteristics and risk factors for patients acquiring carbapenemase-producing and non-carbapenemase-producing carbapenem-nonsusceptible-Enterobacterales bacteremia
by: Alice Ying-Jung Wu, et al.
Published: (2022-12-01)

Epidemiological Characteristics of Carbapenemase Producing Carbapenem-Resistant Enterobacteriaceae Colonization
by: Ihn Sook Jeong, et al.
Published: (2022-08-01)

Occurrence of some common carbapenemase genes in carbapenem-resistant Klebsiella pneumoniae isolates collected from clinical samples in Tabriz, northwestern Iran
by: Abolfazl Jafari-Sales, et al.
Published: (2023-11-01)

The world-wide spread of carbapenem-resistant Enterobacterales
by: Arjana TAMBIC ANDRASEVIC, et al.
Published: (2021-04-01)

The world-wide spread of carbapenem-resistant Enterobacterales
by: Arjana TAMBIC ANDRASEVIC, et al.
Published: (2021-04-01)

Unusual carbapenem resistant but ceftriaxone and cefepime susceptible Klebsiella oxytoca isolated from a blood culture: Case report and whole-genome sequencing investigation
by: Shangxin Yang, et al.
Published: (2018-01-01)

Treatment and Outcomes of Infections Caused by Diverse Carbapenemase-Producing Carbapenem-Resistant Enterobacterales
by: Fang Kang Lim, et al.
Published: (2020-10-01)

Mutational and acquired carbapenem resistance mechanisms in multidrug resistant Pseudomonas aeruginosa clinical isolates from Recife, Brazil
by: Felipe Lira de Sá Cavalcanti, et al.
Published: (2015-12-01)

Comparative analysis of carbapenemases, RND family efflux pumps and biofilm formation potential among Acinetobacter baumannii strains with different carbapenem susceptibility
by: Yanpeng Zhang, et al.
Published: (2021-08-01)

Structural Analysis of The OXA-48 Carbapenemase Bound to A “Poor” Carbapenem Substrate, Doripenem
by: Krisztina M. Papp-Wallace, et al.
Published: (2019-09-01)

Phenotypic determination of carbapenemase producing enterobacteriaceae isolates from clinical specimens at a tertiary hospital in Lagos, Nigeria
by: O O Oduyebo, et al.
Published: (2015-01-01)

Molecular mechanisms of carbapenem resistance among Enterobacteriaceae isolated at Teaching Hospital, Batticaloa
by: M. S. Shihana, et al.
Published: (2021-04-01)

Is It Possible to Eradicate Carbapenem-Resistant <i>Acinetobacter baumannii</i> (CRAB) from Endemic Hospitals?
by: Filippo Medioli, et al.
Published: (2022-07-01)

Carbapenemases from the Laboratory to the Clinic in Gram-Negative Enteric Bacteria
by: Sinem BUDAK, et al.
Published: (2012-12-01)

Quinolone Resistance of <i>Actinobacillus pleuropneumoniae</i> Revealed through Genome and Transcriptome Analyses
by: Xiaoping Ma, et al.
Published: (2021-09-01)

Epidemiological Characteristics of Carbapenem-Resistant <i>Enterobacterales</i> in Japan: A Nationwide Analysis of Data from a Clinical Laboratory Center (2016–2022)
by: Kentarou Takei, et al.
Published: (2023-10-01)

Carbapenem-Resistant Enterobacteriaceae Posing a Dilemma in Effective Healthcare Delivery
by: Angus Nnamdi Oli, et al.
Published: (2019-09-01)

The Carbapenems Issue
by: David Sotello, et al.
Published: (2018-07-01)

Detection of carbapenem-resistant Klebsiella pneumoniae strains harboring carbapenemase, beta-lactamase and quinolone resistance genes in intensive care unit patients
by: Unlu, Ozge, et al.
Published: (2020-11-01)

Clinical Characteristics and Associated Factors for Mortality in Patients with Carbapenem-Resistant <i>Enterobacteriaceae</i> Bloodstream Infection
by: Jin Young Ahn, et al.
Published: (2023-04-01)

Antecedent carbapenem exposure as a risk factor for non-carbapenemase-producing carbapenem-resistant enterobacteriaceae and carbapenemase-producing enterobacteriaceae
by: Marimuthu, Kalisvar, et al.
Published: (2020)

Epidemiology of carbapenem-resistant and carbapenemase-producing Enterobacterales in the Netherlands 2017–2019
by: Cornelia C. H. Wielders, et al.
Published: (2022-04-01)

Estimation, Evaluation and Characterization of Carbapenem Resistance Burden from a Tertiary Care Hospital, Pakistan
by: Aamir Jamal Gondal, et al.
Published: (2023-03-01)

One-Step Differential Detection of OXA-48-Like Variants Using High-Resolution Melting (HRM) Analysis
by: Min Yi Lau, et al.
Published: (2020-05-01)

Phenotypic and genotypic discrepancies for carbapenemase-producing Citrobacter freundii in multiple isolates from a single patient
by: Stephen M. Brecher, et al.
Published: (2023-04-01)

In Vivo Pharmacodynamics of β-Lactams/Nacubactam against Carbapenem-Resistant and/or Carbapenemase-Producing <i>Enterobacter cloacae</i> and <i>Klebsiella pneumoniae</i> in Murine Pneumonia Model
by: Mao Hagihara, et al.
Published: (2021-09-01)

Structural Basis for Carbapenem-Hydrolyzing Mechanisms of Carbapenemases Conferring Antibiotic Resistance
by: Jeong Ho Jeon, et al.
Published: (2015-04-01)

Predictors of Mortality in Patients with Infections Due to Carbapenem-Resistant Gram-Negative Bacteria
by: Hector Orlando Rivera-Villegas, et al.
Published: (2023-06-01)

Carbapenem-Resistant <em>Klebsiella pneumoniae</em> Associated with COVID-19
by: Irina Magdalena Dumitru, et al.
Published: (2021-05-01)