Neuromuscular effects of G93A-SOD1 expression in zebrafish

Neuromuscular effects of G93A-SOD1 expression in zebrafish

<p>Abstract</p> <p>Background</p> <p>Amyotrophic lateral sclerosis (ALS) is a fatal disorder involving the degeneration and loss of motor neurons. The mechanisms of motor neuron loss in ALS are unknown and there are no effective treatments. Defects in the distal axon an...

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Bibliographic Details
Main Authors: Sakowski Stacey A, Lunn J, Busta Angela S, Oh Sang, Zamora-Berridi Grettel, Palmer Madeline, Rosenberg Andrew A, Philip Stephen G, Dowling James J, Feldman Eva L
Format: Article
Language:English
Published: BMC 2012-08-01
Series:Molecular Neurodegeneration
Subjects:
Amyotrophic lateral sclerosis (ALS)
Motor neuron (MN)
Zebrafish
Cu<sup>2+</sup>/Zn<sup>2+</sup> superoxide dismutase (SOD1)
G93A-SOD1
Neuromuscular junction
Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/7/1/44

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