Mycobacterium tuberculosis-macrophage interaction: Molecular updates
Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where it interacts with macrophages. Acidic pH, oxidative and nitrosative stressors, and food restrictions make the macrophage...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1062963/full |
| _version_ | 1811160454486032384 |
|---|---|
| author | Haotian Bo Ulrich Aymard Ekomi Moure Ulrich Aymard Ekomi Moure Yuanmiao Yang Jun Pan Li Li Miao Wang Xiaoxue Ke Xiaoxue Ke Hongjuan Cui Hongjuan Cui Hongjuan Cui |
| author_facet | Haotian Bo Ulrich Aymard Ekomi Moure Ulrich Aymard Ekomi Moure Yuanmiao Yang Jun Pan Li Li Miao Wang Xiaoxue Ke Xiaoxue Ke Hongjuan Cui Hongjuan Cui Hongjuan Cui |
| author_sort | Haotian Bo |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where it interacts with macrophages. Acidic pH, oxidative and nitrosative stressors, and food restrictions make the macrophage’s internal milieu unfriendly to foreign bodies. Mtb subverts the host immune system and causes infection due to its genetic arsenal and secreted effector proteins. In vivo and in vitro research have examined Mtb-host macrophage interaction. This interaction is a crucial stage in Mtb infection because lung macrophages are the first immune cells Mtb encounters in the host. This review summarizes Mtb effectors that interact with macrophages. It also examines how macrophages control and eliminate Mtb and how Mtb manipulates macrophage defense mechanisms for its own survival. Understanding these mechanisms is crucial for TB prevention, diagnosis, and treatment. |
| first_indexed | 2024-04-10T05:57:36Z |
| format | Article |
| id | doaj.art-b64df375f9b84fca94c393e69b9bd5a1 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-10T05:57:36Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b64df375f9b84fca94c393e69b9bd5a12023-03-03T09:54:43ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-03-011310.3389/fcimb.2023.10629631062963Mycobacterium tuberculosis-macrophage interaction: Molecular updatesHaotian Bo0Ulrich Aymard Ekomi Moure1Ulrich Aymard Ekomi Moure2Yuanmiao Yang3Jun Pan4Li Li5Miao Wang6Xiaoxue Ke7Xiaoxue Ke8Hongjuan Cui9Hongjuan Cui10Hongjuan Cui11State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaThe Ninth People's Hospital of Chongqing, Affiliated Hospital of Southwest University, Chongqing, ChinaCancer Center, Medical Research Institute, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaCancer Center, Medical Research Institute, Southwest University, Chongqing, ChinaCancer Center, Medical Research Institute, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaCancer Center, Medical Research Institute, Southwest University, Chongqing, ChinaState Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing, ChinaCancer Center, Medical Research Institute, Southwest University, Chongqing, ChinaJinfeng Laboratory, Chongqing, ChinaMycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where it interacts with macrophages. Acidic pH, oxidative and nitrosative stressors, and food restrictions make the macrophage’s internal milieu unfriendly to foreign bodies. Mtb subverts the host immune system and causes infection due to its genetic arsenal and secreted effector proteins. In vivo and in vitro research have examined Mtb-host macrophage interaction. This interaction is a crucial stage in Mtb infection because lung macrophages are the first immune cells Mtb encounters in the host. This review summarizes Mtb effectors that interact with macrophages. It also examines how macrophages control and eliminate Mtb and how Mtb manipulates macrophage defense mechanisms for its own survival. Understanding these mechanisms is crucial for TB prevention, diagnosis, and treatment.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1062963/fullintracellular pathogenMycobacterium tuberculosishost macrophagemolecular interactionimmune controlimmune evasion |
| spellingShingle | Haotian Bo Ulrich Aymard Ekomi Moure Ulrich Aymard Ekomi Moure Yuanmiao Yang Jun Pan Li Li Miao Wang Xiaoxue Ke Xiaoxue Ke Hongjuan Cui Hongjuan Cui Hongjuan Cui Mycobacterium tuberculosis-macrophage interaction: Molecular updates Frontiers in Cellular and Infection Microbiology intracellular pathogen Mycobacterium tuberculosis host macrophage molecular interaction immune control immune evasion |
| title | Mycobacterium tuberculosis-macrophage interaction: Molecular updates |
| title_full | Mycobacterium tuberculosis-macrophage interaction: Molecular updates |
| title_fullStr | Mycobacterium tuberculosis-macrophage interaction: Molecular updates |
| title_full_unstemmed | Mycobacterium tuberculosis-macrophage interaction: Molecular updates |
| title_short | Mycobacterium tuberculosis-macrophage interaction: Molecular updates |
| title_sort | mycobacterium tuberculosis macrophage interaction molecular updates |
| topic | intracellular pathogen Mycobacterium tuberculosis host macrophage molecular interaction immune control immune evasion |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1062963/full |
| work_keys_str_mv | AT haotianbo mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT ulrichaymardekomimoure mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT ulrichaymardekomimoure mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT yuanmiaoyang mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT junpan mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT lili mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT miaowang mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT xiaoxueke mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT xiaoxueke mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT hongjuancui mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT hongjuancui mycobacteriumtuberculosismacrophageinteractionmolecularupdates AT hongjuancui mycobacteriumtuberculosismacrophageinteractionmolecularupdates |