The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug?
Thymic epithelial tumors are rare tumors usually presenting as a mass located in the anterior mediastinum and/or with symptoms deriving from associated paraneoplastic syndromes. Unresectable platinum-refractory tumors are often treated with alternative regimens, including chemotherapeutic agents as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/774 |
| _version_ | 1797488666724007936 |
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| author | Liliana Montella Margaret Ottaviano Rocco Morra Erica Pietroluongo Pietro De Placido Marianna Tortora Chiara Sorrentino Gaetano Facchini Sabino De Placido Mario Giuliano Giovannella Palmieri |
| author_facet | Liliana Montella Margaret Ottaviano Rocco Morra Erica Pietroluongo Pietro De Placido Marianna Tortora Chiara Sorrentino Gaetano Facchini Sabino De Placido Mario Giuliano Giovannella Palmieri |
| author_sort | Liliana Montella |
| collection | DOAJ |
| description | Thymic epithelial tumors are rare tumors usually presenting as a mass located in the anterior mediastinum and/or with symptoms deriving from associated paraneoplastic syndromes. Unresectable platinum-refractory tumors are often treated with alternative regimens, including chemotherapeutic agents as well as chemo-free regimens. The most popular unconventional therapy is represented by the somatostatin analog octreotide, which can be used alone or with prednisone. The in vivo expression of somatostatin receptors documented by imaging with indium-labeled octreotide or gallium-68 Dotapeptides, the successful use of octreotide and prednisone in a chemo-refractory patient, and, thereafter, the experiences from a case series have enforced the idea that this treatment merits consideration—as proved by its inclusion in the National Comprehensive Cancer Network guidelines. In the present review, we analyze the preclinical basis for the therapeutic use of somatostatin and prednisone in refractory thymic tumors and discuss the available studies looking at future perspectives. |
| first_indexed | 2024-03-10T00:06:34Z |
| format | Article |
| id | doaj.art-b64e38bc23f34ad3aa399a3507dcf516 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:06:34Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-b64e38bc23f34ad3aa399a3507dcf5162023-11-23T16:08:25ZengMDPI AGCancers2072-66942022-02-0114377410.3390/cancers14030774The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug?Liliana Montella0Margaret Ottaviano1Rocco Morra2Erica Pietroluongo3Pietro De Placido4Marianna Tortora5Chiara Sorrentino6Gaetano Facchini7Sabino De Placido8Mario Giuliano9Giovannella Palmieri10ASL NA2 NORD, Oncology Operative Unit, “Santa Maria delle Grazie” Hospital, 80078 Pozzuoli, ItalyOncology Unit, Ospedale del Mare, 80147 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyASL NA2 NORD, Oncology Operative Unit, “Santa Maria delle Grazie” Hospital, 80078 Pozzuoli, ItalyCRCTR Coordinating Rare Tumors Reference Center of Campania Region, 80131 Naples, ItalyCRCTR Coordinating Rare Tumors Reference Center of Campania Region, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, Università degli Studi di Napoli “Federico II”, 80131 Naples, ItalyThymic epithelial tumors are rare tumors usually presenting as a mass located in the anterior mediastinum and/or with symptoms deriving from associated paraneoplastic syndromes. Unresectable platinum-refractory tumors are often treated with alternative regimens, including chemotherapeutic agents as well as chemo-free regimens. The most popular unconventional therapy is represented by the somatostatin analog octreotide, which can be used alone or with prednisone. The in vivo expression of somatostatin receptors documented by imaging with indium-labeled octreotide or gallium-68 Dotapeptides, the successful use of octreotide and prednisone in a chemo-refractory patient, and, thereafter, the experiences from a case series have enforced the idea that this treatment merits consideration—as proved by its inclusion in the National Comprehensive Cancer Network guidelines. In the present review, we analyze the preclinical basis for the therapeutic use of somatostatin and prednisone in refractory thymic tumors and discuss the available studies looking at future perspectives.https://www.mdpi.com/2072-6694/14/3/774thymic epithelial tumorsthymomathymic carcinomatargeted therapysomatostatinoctreotide |
| spellingShingle | Liliana Montella Margaret Ottaviano Rocco Morra Erica Pietroluongo Pietro De Placido Marianna Tortora Chiara Sorrentino Gaetano Facchini Sabino De Placido Mario Giuliano Giovannella Palmieri The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? Cancers thymic epithelial tumors thymoma thymic carcinoma targeted therapy somatostatin octreotide |
| title | The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? |
| title_full | The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? |
| title_fullStr | The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? |
| title_full_unstemmed | The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? |
| title_short | The Never-Ending History of Octreotide in Thymic Tumors: A Vintage or A Contemporary Drug? |
| title_sort | never ending history of octreotide in thymic tumors a vintage or a contemporary drug |
| topic | thymic epithelial tumors thymoma thymic carcinoma targeted therapy somatostatin octreotide |
| url | https://www.mdpi.com/2072-6694/14/3/774 |
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