The Role of BDNF in Multiple Sclerosis Neuroinflammation
Multiple sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central nervous system (CNS). Inflammation is observed in all stages of MS, both within and around the lesions, and can have beneficial and detrimental effects on MS pathogenesis. A possible mechanism for the neuropr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/9/8447 |
| _version_ | 1797602395907162112 |
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| author | Viviana Nociti Marina Romozzi |
| author_facet | Viviana Nociti Marina Romozzi |
| author_sort | Viviana Nociti |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central nervous system (CNS). Inflammation is observed in all stages of MS, both within and around the lesions, and can have beneficial and detrimental effects on MS pathogenesis. A possible mechanism for the neuroprotective effect in MS involves the release of brain-derived neurotrophic factor (BDNF) by immune cells in peripheral blood and inflammatory lesions, as well as by microglia and astrocytes within the CNS. BDNF is a neurotrophic factor that plays a key role in neuroplasticity and neuronal survival. This review aims to analyze the current understanding of the role that inflammation plays in MS, including the factors that contribute to both beneficial and detrimental effects. Additionally, it explores the potential role of BDNF in MS, as it may modulate neuroinflammation and provide neuroprotection. By obtaining a deeper understanding of the intricate relationship between inflammation and BDNF, new therapeutic strategies for MS may be developed. |
| first_indexed | 2024-03-11T04:15:29Z |
| format | Article |
| id | doaj.art-b64f5b84f6b64e8c8d73c4b659653fcc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:15:29Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b64f5b84f6b64e8c8d73c4b659653fcc2023-11-17T23:09:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-01249844710.3390/ijms24098447The Role of BDNF in Multiple Sclerosis NeuroinflammationViviana Nociti0Marina Romozzi1Institute of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyInstitute of Neurology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, ItalyMultiple sclerosis (MS) is a chronic, inflammatory, and degenerative disease of the central nervous system (CNS). Inflammation is observed in all stages of MS, both within and around the lesions, and can have beneficial and detrimental effects on MS pathogenesis. A possible mechanism for the neuroprotective effect in MS involves the release of brain-derived neurotrophic factor (BDNF) by immune cells in peripheral blood and inflammatory lesions, as well as by microglia and astrocytes within the CNS. BDNF is a neurotrophic factor that plays a key role in neuroplasticity and neuronal survival. This review aims to analyze the current understanding of the role that inflammation plays in MS, including the factors that contribute to both beneficial and detrimental effects. Additionally, it explores the potential role of BDNF in MS, as it may modulate neuroinflammation and provide neuroprotection. By obtaining a deeper understanding of the intricate relationship between inflammation and BDNF, new therapeutic strategies for MS may be developed.https://www.mdpi.com/1422-0067/24/9/8447MSbrain-derived neurotrophic factorneuroprotectionneurotrophinCNS inflammationdemyelinating diseases |
| spellingShingle | Viviana Nociti Marina Romozzi The Role of BDNF in Multiple Sclerosis Neuroinflammation International Journal of Molecular Sciences MS brain-derived neurotrophic factor neuroprotection neurotrophin CNS inflammation demyelinating diseases |
| title | The Role of BDNF in Multiple Sclerosis Neuroinflammation |
| title_full | The Role of BDNF in Multiple Sclerosis Neuroinflammation |
| title_fullStr | The Role of BDNF in Multiple Sclerosis Neuroinflammation |
| title_full_unstemmed | The Role of BDNF in Multiple Sclerosis Neuroinflammation |
| title_short | The Role of BDNF in Multiple Sclerosis Neuroinflammation |
| title_sort | role of bdnf in multiple sclerosis neuroinflammation |
| topic | MS brain-derived neurotrophic factor neuroprotection neurotrophin CNS inflammation demyelinating diseases |
| url | https://www.mdpi.com/1422-0067/24/9/8447 |
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