Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest

Indole-3-Carbinol, a Phytochemical Aryl Hydrocarbon Receptor-Ligand, Induces the mRNA Overexpression of UBE2L3 and Cell Proliferation Arrest

Cervical cancer (CC) is one of the most common cancers in women, and is linked to human papillomavirus (HPV) infection. The virus oncoprotein E6 binds to p53, resulting in its degradation and allowing uncontrolled cell proliferation. Meanwhile, the HPV E7 protein maintains host cell differentiation...

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Bibliographic Details
Main Authors: Claudia Vanessa Arellano-Gutiérrez, Laura Itzel Quintas-Granados, Hernán Cortés, Manuel González del Carmen, Gerardo Leyva-Gómez, Lilia Patricia Bustamante-Montes, Miguel Rodríguez-Morales, Israel López-Reyes, Juan Ramón Padilla-Mendoza, Lorena Rodríguez-Páez, Gabriela Figueroa-González, Octavio Daniel Reyes-Hernández
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Current Issues in Molecular Biology
Subjects:
cervical cancer
indole-3-carbinol
<i>UBE2L3</i>
cellular proliferation
Online Access:https://www.mdpi.com/1467-3045/44/5/139

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https://www.mdpi.com/1467-3045/44/5/139

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