Microbiota–Liver Diseases Interactions
Gut microbiota regulates essential processes of host metabolism and physiology: synthesis of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most important—protects the digestive tract from pathogens. In this study, we focus on the CRISPR/Cas9 technology, which is exten...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/4/3883 |
| _version_ | 1797620491089870848 |
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| author | Rosanna Capparelli Paola Cuomo Antonio Gentile Domenico Iannelli |
| author_facet | Rosanna Capparelli Paola Cuomo Antonio Gentile Domenico Iannelli |
| author_sort | Rosanna Capparelli |
| collection | DOAJ |
| description | Gut microbiota regulates essential processes of host metabolism and physiology: synthesis of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most important—protects the digestive tract from pathogens. In this study, we focus on the CRISPR/Cas9 technology, which is extensively used to correct multiple diseases, including liver diseases. Then, we discuss the non-alcoholic fatty liver disease (NAFLD), affecting more than 25% of the global population; colorectal cancer (CRC) is second in mortality. We give space to rarely discussed topics, such as pathobionts and multiple mutations. Pathobionts help to understand the origin and complexity of the microbiota. Since several types of cancers have as target the gut, it is vital extending the research of multiple mutations to the type of cancers affecting the gut–liver axis. |
| first_indexed | 2024-03-11T08:42:13Z |
| format | Article |
| id | doaj.art-b650918e62344387a679d33d1b12f173 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:42:13Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b650918e62344387a679d33d1b12f1732023-11-16T21:06:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244388310.3390/ijms24043883Microbiota–Liver Diseases InteractionsRosanna Capparelli0Paola Cuomo1Antonio Gentile2Domenico Iannelli3Department of Agriculture Sciences, University of Naples Federico II, 80055 Naples, ItalyDepartment of Agriculture Sciences, University of Naples Federico II, 80055 Naples, ItalyDepartment of Agriculture Sciences, University of Naples Federico II, 80055 Naples, ItalyDepartment of Agriculture Sciences, University of Naples Federico II, 80055 Naples, ItalyGut microbiota regulates essential processes of host metabolism and physiology: synthesis of vitamins, digestion of foods non-digestible by the host (such as fibers), and—most important—protects the digestive tract from pathogens. In this study, we focus on the CRISPR/Cas9 technology, which is extensively used to correct multiple diseases, including liver diseases. Then, we discuss the non-alcoholic fatty liver disease (NAFLD), affecting more than 25% of the global population; colorectal cancer (CRC) is second in mortality. We give space to rarely discussed topics, such as pathobionts and multiple mutations. Pathobionts help to understand the origin and complexity of the microbiota. Since several types of cancers have as target the gut, it is vital extending the research of multiple mutations to the type of cancers affecting the gut–liver axis.https://www.mdpi.com/1422-0067/24/4/3883gut–microbiotapathobiontsliver diseases |
| spellingShingle | Rosanna Capparelli Paola Cuomo Antonio Gentile Domenico Iannelli Microbiota–Liver Diseases Interactions International Journal of Molecular Sciences gut–microbiota pathobionts liver diseases |
| title | Microbiota–Liver Diseases Interactions |
| title_full | Microbiota–Liver Diseases Interactions |
| title_fullStr | Microbiota–Liver Diseases Interactions |
| title_full_unstemmed | Microbiota–Liver Diseases Interactions |
| title_short | Microbiota–Liver Diseases Interactions |
| title_sort | microbiota liver diseases interactions |
| topic | gut–microbiota pathobionts liver diseases |
| url | https://www.mdpi.com/1422-0067/24/4/3883 |
| work_keys_str_mv | AT rosannacapparelli microbiotaliverdiseasesinteractions AT paolacuomo microbiotaliverdiseasesinteractions AT antoniogentile microbiotaliverdiseasesinteractions AT domenicoiannelli microbiotaliverdiseasesinteractions |