Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells
The purpose of the study was to compare cytotoxicity of two <i>Quillaja saponaria</i> bark saponin (QBS) mixtures against two lung cell lines: normal MRC-5 fibroblast cell line and tumor A-549 epithelial cells of lungs’ alveoli. The study, performed both at a macro-scale and in a dedicat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Biophysica |
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| Online Access: | https://www.mdpi.com/2673-4125/1/2/10 |
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| author | Natalia Kozińska Katarzyna Tokarska Michał Chudy Kamil Wojciechowski |
| author_facet | Natalia Kozińska Katarzyna Tokarska Michał Chudy Kamil Wojciechowski |
| author_sort | Natalia Kozińska |
| collection | DOAJ |
| description | The purpose of the study was to compare cytotoxicity of two <i>Quillaja saponaria</i> bark saponin (QBS) mixtures against two lung cell lines: normal MRC-5 fibroblast cell line and tumor A-549 epithelial cells of lungs’ alveoli. The study, performed both at a macro-scale and in a dedicated microfluidic device, showed that QBS was more toxic to the cell line more abundant in cholesterol (MRC-5). The QBS mixture with higher saponin fraction was found to be more cytotoxic towards both cell lines. The results may help to better understand the cytotoxicity of saponin-rich herbal medicines towards normal and tumor cells depending on their cholesterol content. |
| first_indexed | 2024-03-10T08:58:44Z |
| format | Article |
| id | doaj.art-b652db20b8914fcfb54536c94eecebbf |
| institution | Directory Open Access Journal |
| issn | 2673-4125 |
| language | English |
| last_indexed | 2024-03-10T08:58:44Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biophysica |
| spelling | doaj.art-b652db20b8914fcfb54536c94eecebbf2023-11-22T06:57:08ZengMDPI AGBiophysica2673-41252021-04-011212613610.3390/biophysica1020010Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich CellsNatalia Kozińska0Katarzyna Tokarska1Michał Chudy2Kamil Wojciechowski3Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, PolandThe purpose of the study was to compare cytotoxicity of two <i>Quillaja saponaria</i> bark saponin (QBS) mixtures against two lung cell lines: normal MRC-5 fibroblast cell line and tumor A-549 epithelial cells of lungs’ alveoli. The study, performed both at a macro-scale and in a dedicated microfluidic device, showed that QBS was more toxic to the cell line more abundant in cholesterol (MRC-5). The QBS mixture with higher saponin fraction was found to be more cytotoxic towards both cell lines. The results may help to better understand the cytotoxicity of saponin-rich herbal medicines towards normal and tumor cells depending on their cholesterol content.https://www.mdpi.com/2673-4125/1/2/10MRC-5A549cytotoxicitysaponinsmicrofluidics |
| spellingShingle | Natalia Kozińska Katarzyna Tokarska Michał Chudy Kamil Wojciechowski Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells Biophysica MRC-5 A549 cytotoxicity saponins microfluidics |
| title | Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells |
| title_full | Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells |
| title_fullStr | Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells |
| title_full_unstemmed | Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells |
| title_short | Cytotoxicity of <i>Quillaja saponaria</i> Saponins towards Lung Cells Is Higher for Cholesterol-Rich Cells |
| title_sort | cytotoxicity of i quillaja saponaria i saponins towards lung cells is higher for cholesterol rich cells |
| topic | MRC-5 A549 cytotoxicity saponins microfluidics |
| url | https://www.mdpi.com/2673-4125/1/2/10 |
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