Spitz Melanocytic Tumors: A Fascinating 75-Year Journey
Over the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type of melanoma, the perception has shifted towards recognizing Spitz lesions as a spectrum comprising Spitz nevi, Spitz melanocytomas, and Spitz melanomas. Spitz lesions...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Genes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4425/15/2/195 |
| _version_ | 1797298163789332480 |
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| author | Kyriakos Chatzopoulos Antonia Syrnioti Konstantinos Linos |
| author_facet | Kyriakos Chatzopoulos Antonia Syrnioti Konstantinos Linos |
| author_sort | Kyriakos Chatzopoulos |
| collection | DOAJ |
| description | Over the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type of melanoma, the perception has shifted towards recognizing Spitz lesions as a spectrum comprising Spitz nevi, Spitz melanocytomas, and Spitz melanomas. Spitz lesions are known for posing a significant diagnostic challenge regarding the distinction between benign neoplasms displaying atypical traits and melanomas. A comprehensive understanding of their molecular basis and genomic aberrations has significantly improved precision in classifying and diagnosing these challenging lesions. The primary aim of this review is to encapsulate the current understanding of the molecular pathogenesis and distinct clinicopathologic characteristics defining this intriguing set of tumors. |
| first_indexed | 2024-03-07T22:31:56Z |
| format | Article |
| id | doaj.art-b652ff4991d24087abe181bcf8fbf323 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-07T22:31:56Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-b652ff4991d24087abe181bcf8fbf3232024-02-23T15:17:48ZengMDPI AGGenes2073-44252024-01-0115219510.3390/genes15020195Spitz Melanocytic Tumors: A Fascinating 75-Year JourneyKyriakos Chatzopoulos0Antonia Syrnioti1Konstantinos Linos2Department of Pathology, Aristotle University, 54636 Thessaloniki, GreeceDepartment of Pathology, Aristotle University, 54636 Thessaloniki, GreeceDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USAOver the last 75 years, our understanding of Spitz lesions has undergone substantial evolution. Initially considered a specific type of melanoma, the perception has shifted towards recognizing Spitz lesions as a spectrum comprising Spitz nevi, Spitz melanocytomas, and Spitz melanomas. Spitz lesions are known for posing a significant diagnostic challenge regarding the distinction between benign neoplasms displaying atypical traits and melanomas. A comprehensive understanding of their molecular basis and genomic aberrations has significantly improved precision in classifying and diagnosing these challenging lesions. The primary aim of this review is to encapsulate the current understanding of the molecular pathogenesis and distinct clinicopathologic characteristics defining this intriguing set of tumors.https://www.mdpi.com/2073-4425/15/2/195spitzspitzoidmelanocyticatypical spitz tumormelanomanevus |
| spellingShingle | Kyriakos Chatzopoulos Antonia Syrnioti Konstantinos Linos Spitz Melanocytic Tumors: A Fascinating 75-Year Journey Genes spitz spitzoid melanocytic atypical spitz tumor melanoma nevus |
| title | Spitz Melanocytic Tumors: A Fascinating 75-Year Journey |
| title_full | Spitz Melanocytic Tumors: A Fascinating 75-Year Journey |
| title_fullStr | Spitz Melanocytic Tumors: A Fascinating 75-Year Journey |
| title_full_unstemmed | Spitz Melanocytic Tumors: A Fascinating 75-Year Journey |
| title_short | Spitz Melanocytic Tumors: A Fascinating 75-Year Journey |
| title_sort | spitz melanocytic tumors a fascinating 75 year journey |
| topic | spitz spitzoid melanocytic atypical spitz tumor melanoma nevus |
| url | https://www.mdpi.com/2073-4425/15/2/195 |
| work_keys_str_mv | AT kyriakoschatzopoulos spitzmelanocytictumorsafascinating75yearjourney AT antoniasyrnioti spitzmelanocytictumorsafascinating75yearjourney AT konstantinoslinos spitzmelanocytictumorsafascinating75yearjourney |