Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation

Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation

Abstract Gabapentin has antihyperalgesic action, decreasing central sensitization in neuropathic pain models; this effect depends on the mobilization of endogenous pain control pathways. This study aims to investigate the contribution of the endocannabinoid system to the antihyperalgesic action of g...

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Bibliographic Details
Main Authors: ALEXANDRE C. BUFFON, MARCELO A. JAVORNIK, ANA C. HEYMANNS, DAIANA C. SALM, VERÔNICA V. HOREWICZ, DANIEL F. MARTINS, ANNA P. PIOVEZAN
Format: Article
Language:English
Published: Academia Brasileira de Ciências 2020-12-01
Series:Anais da Academia Brasileira de Ciências
Subjects:
Endocannabinoid
gabapentin
hyperalgesia
nerve ligation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700939&tlng=en

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