Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies
Adult neurogenesis is the process of differentiation of neural stem cells (NSCs) into neurons and glial cells in certain areas of the adult brain. Defects in neurogenesis can lead to neurodegenerative diseases, mental disorders, and other maladies. This process is directionally regulated by transcri...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1072341/full |
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| author | Chenxi Zhang Peng Xue Haiyan Zhang Chenxi Tan Shiyao Zhao Xudong Li Lihui Sun Huihui Zheng Jun Wang Baoling Zhang Weiya Lang |
| author_facet | Chenxi Zhang Peng Xue Haiyan Zhang Chenxi Tan Shiyao Zhao Xudong Li Lihui Sun Huihui Zheng Jun Wang Baoling Zhang Weiya Lang |
| author_sort | Chenxi Zhang |
| collection | DOAJ |
| description | Adult neurogenesis is the process of differentiation of neural stem cells (NSCs) into neurons and glial cells in certain areas of the adult brain. Defects in neurogenesis can lead to neurodegenerative diseases, mental disorders, and other maladies. This process is directionally regulated by transcription factors, the Wnt and Notch pathway, the extracellular matrix, and various growth factors. External factors like stress, physical exercise, diet, medications, etc., affect neurogenesis and the gut microbiota. The gut microbiota may affect NSCs through vagal, immune and chemical pathways, and other pathways. Traditional Chinese medicine (TCM) has been proven to affect NSCs proliferation and differentiation and can regulate the abundance and metabolites produced by intestinal microorganisms. However, the underlying mechanisms by which these factors regulate neurogenesis through the gut microbiota are not fully understood. In this review, we describe the recent evidence on the role of the gut microbiota in neurogenesis. Moreover, we hypothesize on the characteristics of the microbiota-gut-brain axis based on bacterial phyla, including microbiota’s metabolites, and neuronal and immune pathways while providing an outlook on TCM’s potential effects on adult neurogenesis by regulating gut microbiota. |
| first_indexed | 2024-04-11T13:34:38Z |
| format | Article |
| id | doaj.art-b6540a7643eb4ecf9dafcc83c234d685 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T13:34:38Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b6540a7643eb4ecf9dafcc83c234d6852022-12-22T04:21:38ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-12-011210.3389/fcimb.2022.10723411072341Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategiesChenxi Zhang0Peng Xue1Haiyan Zhang2Chenxi Tan3Shiyao Zhao4Xudong Li5Lihui Sun6Huihui Zheng7Jun Wang8Baoling Zhang9Weiya Lang10Basic Medical Science College, Qiqihar Medical University, Qiqihar, ChinaMedical School of Nantong University, Nantong University, Nantong, ChinaBasic Medical Science College, Qiqihar Medical University, Qiqihar, ChinaDepartment of Infection Control, The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, ChinaDepartment of Nuclear Medicine, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, ChinaDepartment of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, ChinaBasic Medical Science College, Qiqihar Medical University, Qiqihar, ChinaBasic Medical Science College, Qiqihar Medical University, Qiqihar, ChinaThe Academic Affairs Office, Qiqihar Medical University, Qiqihar, ChinaDepartment of Operating Room, Qiqihar First Hospital, Qiqihar, ChinaBasic Medical Science College, Qiqihar Medical University, Qiqihar, ChinaAdult neurogenesis is the process of differentiation of neural stem cells (NSCs) into neurons and glial cells in certain areas of the adult brain. Defects in neurogenesis can lead to neurodegenerative diseases, mental disorders, and other maladies. This process is directionally regulated by transcription factors, the Wnt and Notch pathway, the extracellular matrix, and various growth factors. External factors like stress, physical exercise, diet, medications, etc., affect neurogenesis and the gut microbiota. The gut microbiota may affect NSCs through vagal, immune and chemical pathways, and other pathways. Traditional Chinese medicine (TCM) has been proven to affect NSCs proliferation and differentiation and can regulate the abundance and metabolites produced by intestinal microorganisms. However, the underlying mechanisms by which these factors regulate neurogenesis through the gut microbiota are not fully understood. In this review, we describe the recent evidence on the role of the gut microbiota in neurogenesis. Moreover, we hypothesize on the characteristics of the microbiota-gut-brain axis based on bacterial phyla, including microbiota’s metabolites, and neuronal and immune pathways while providing an outlook on TCM’s potential effects on adult neurogenesis by regulating gut microbiota.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1072341/fullneurogenesisgut microbiotatraditional Chinese medicinemicrobiota-gut-brain axis (MGB axis)neural stem cell (NSC) |
| spellingShingle | Chenxi Zhang Peng Xue Haiyan Zhang Chenxi Tan Shiyao Zhao Xudong Li Lihui Sun Huihui Zheng Jun Wang Baoling Zhang Weiya Lang Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies Frontiers in Cellular and Infection Microbiology neurogenesis gut microbiota traditional Chinese medicine microbiota-gut-brain axis (MGB axis) neural stem cell (NSC) |
| title | Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies |
| title_full | Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies |
| title_fullStr | Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies |
| title_full_unstemmed | Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies |
| title_short | Gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional Chinese medicine research strategies |
| title_sort | gut brain interaction theory reveals gut microbiota mediated neurogenesis and traditional chinese medicine research strategies |
| topic | neurogenesis gut microbiota traditional Chinese medicine microbiota-gut-brain axis (MGB axis) neural stem cell (NSC) |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1072341/full |
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