Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview
Radiation-induced damages are difficult to heal than normal wounds. This is because radiation therapy could lead to an imbalanced inflammatory response, oxidative stress response, lack of angiogenesis, and a high risk of bacterial infection, which are considered to be the greatest challenges in radi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Materials |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmats.2022.1018815/full |
| _version_ | 1817984507268038656 |
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| author | Yidan Su Hengqing Cui Chao Yang Lu Li Fei Xu Jie Gao Wenjun Zhang |
| author_facet | Yidan Su Hengqing Cui Chao Yang Lu Li Fei Xu Jie Gao Wenjun Zhang |
| author_sort | Yidan Su |
| collection | DOAJ |
| description | Radiation-induced damages are difficult to heal than normal wounds. This is because radiation therapy could lead to an imbalanced inflammatory response, oxidative stress response, lack of angiogenesis, and a high risk of bacterial infection, which are considered to be the greatest challenges in radiation-induced damages treatment. Hydrogels are semi-occlusive and are composed of complex hydrophilic polymers with a higher water content. Due to their excellent mechanical and biochemical property (such as adhesiveness, antibacterial, and antioxidant abilities), hydrogels represent a promising strategy that has achieved potent therapeutic efficacy in the treatment of radiation-induced skin and mucosa damages. This review systematically and comprehensively summarizes the recent progress of various types of hydrogels such as natural biopolymer, synthetic polymer, composite hydrogels and commodity dressings for the treatment of radiation-induced skin and mucosa damages. |
| first_indexed | 2024-04-13T23:45:36Z |
| format | Article |
| id | doaj.art-b654e45906334f4292e06970c731795c |
| institution | Directory Open Access Journal |
| issn | 2296-8016 |
| language | English |
| last_indexed | 2024-04-13T23:45:36Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Materials |
| spelling | doaj.art-b654e45906334f4292e06970c731795c2022-12-22T02:24:20ZengFrontiers Media S.A.Frontiers in Materials2296-80162022-10-01910.3389/fmats.2022.10188151018815Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overviewYidan Su0Hengqing Cui1Chao Yang2Lu Li3Fei Xu4Jie Gao5Wenjun Zhang6Department of Burn and Plastic Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaDepartment of Burn and Plastic Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaDepartment of Plastic Surgery, Naval Medical Center, Naval Medical University, Shanghai, ChinaDepartment of Plastic Surgery, Naval Medical Center, Naval Medical University, Shanghai, ChinaDepartment of Plastic Surgery, Naval Medical Center, Naval Medical University, Shanghai, ChinaChanghai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, ChinaDepartment of Burn and Plastic Surgery, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, ChinaRadiation-induced damages are difficult to heal than normal wounds. This is because radiation therapy could lead to an imbalanced inflammatory response, oxidative stress response, lack of angiogenesis, and a high risk of bacterial infection, which are considered to be the greatest challenges in radiation-induced damages treatment. Hydrogels are semi-occlusive and are composed of complex hydrophilic polymers with a higher water content. Due to their excellent mechanical and biochemical property (such as adhesiveness, antibacterial, and antioxidant abilities), hydrogels represent a promising strategy that has achieved potent therapeutic efficacy in the treatment of radiation-induced skin and mucosa damages. This review systematically and comprehensively summarizes the recent progress of various types of hydrogels such as natural biopolymer, synthetic polymer, composite hydrogels and commodity dressings for the treatment of radiation-induced skin and mucosa damages.https://www.frontiersin.org/articles/10.3389/fmats.2022.1018815/fullradiation therapyskin and mucosa damageswound healingtissue regenerationhydrogel dressings |
| spellingShingle | Yidan Su Hengqing Cui Chao Yang Lu Li Fei Xu Jie Gao Wenjun Zhang Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview Frontiers in Materials radiation therapy skin and mucosa damages wound healing tissue regeneration hydrogel dressings |
| title | Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview |
| title_full | Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview |
| title_fullStr | Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview |
| title_full_unstemmed | Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview |
| title_short | Hydrogels for the treatment of radiation-induced skin and mucosa damages: An up-to-date overview |
| title_sort | hydrogels for the treatment of radiation induced skin and mucosa damages an up to date overview |
| topic | radiation therapy skin and mucosa damages wound healing tissue regeneration hydrogel dressings |
| url | https://www.frontiersin.org/articles/10.3389/fmats.2022.1018815/full |
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