Studies on 2-Arylhydrazononitriles: Synthesis of 3-Aryl-2-arylhydrazopropanenitriles and Their Utility as Precursors to 2-Substituted Indoles, 2-Substituted-1,2,3-Triazoles, and 1-Substituted Pyrazolo[4,3-d]pyrimidines

Studies on 2-Arylhydrazononitriles: Synthesis of 3-Aryl-2-arylhydrazopropanenitriles and Their Utility as Precursors to 2-Substituted Indoles, 2-Substituted-1,2,3-Triazoles, and 1-Substituted Pyrazolo[4,3-d]pyrimidines

Coupling of 2-benzylmalononitrile with aromatic diazonium salts afforded 3-phenyl-2-arylhydrazonopropanenitriles 4a,b, which were rearranged into 2-cyanoindoles 5a,b upon heating with ZnCl2 in the presence of glacial acetic acid. The produced indole derivatives 5a,b can be successfully used as valua...

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Bibliographic Details
Main Authors:	Khaled D. Khalil, Hamad M. Al-Matar
Format:	Article
Language:	English
Published:	MDPI AG 2012-10-01
Series:	Molecules
Subjects:	benzylidenemalononitrile 2-arylhydrazononitrile amidoxime cyanoindole dimethylformamide dimethylacetal 1,2,3-triazole
Online Access:	http://www.mdpi.com/1420-3049/17/10/12225

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