Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making
Objective: To evaluate a pilot of a laboratory model for relating pharmacogenetics to clinical decision making. Case Study: This pilot was undertaken and evaluated to help determine if a pharmacogenetics laboratory should be included in the core Doctor of Pharmacy curriculum. The placement of the la...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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University of Minnesota Libraries Publishing
2013-01-01
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| Series: | INNOVATIONS in Pharmacy |
| Subjects: | |
| Online Access: | http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_445106.pdf |
| _version_ | 1819132265854140416 |
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| author | Angela Smith, PharmD Candidate Amy L. Stockert, PhD Jeffery N. Talbot, PhD, David F. Kisor, BS, PharmD |
| author_facet | Angela Smith, PharmD Candidate Amy L. Stockert, PhD Jeffery N. Talbot, PhD, David F. Kisor, BS, PharmD |
| author_sort | Angela Smith, PharmD Candidate |
| collection | DOAJ |
| description | Objective: To evaluate a pilot of a laboratory model for relating pharmacogenetics to clinical decision making. Case Study: This pilot was undertaken and evaluated to help determine if a pharmacogenetics laboratory should be included in the core Doctor of Pharmacy curriculum. The placement of the laboratory exercise in the curriculum was determined by identifying the point in the curriculum where the students had been introduced to the chemistry of deoxyribonucleic acid (DNA) as well as instructed on the chemistry of genetic variation. The laboratory included cytochrome P450 2C19 genotyping relative to the *2 variant. Twenty-four students served as the pilot group. Students provided buccal swabs as the source of DNA. Students stabilized the samples and were then provided instructions related to sample preparation, polymerase chain reaction, and gel electrophoresis. The results were reported as images of gels. Students used a reference gel image to compare their results to. Students then applied a dosing algorithm to make a “clinical decision” relative to clopidogrel use. Students were offered a post laboratory survey regarding attitudes toward the laboratory. Twenty-four students completed the laboratory with genotyping results being provided for 22 students (91.7%). Sixteen students were wild-type (*1/*1), while six students were heterozygous (*1/*2). Twenty-three students (96%) completed the post laboratory survey. All 23 agreed (6, 26.1%) or strongly agreed (17, 73.9%) that the laboratory “had relevance and value in the pharmacy curriculum”. Conclusion: The post pilot study survey exploring a laboratory model for pharmacogenetics related to clinical decision making indicated that such a laboratory would be viewed positively by students. This model may be adopted by colleges to expand pharmacogenetics education. |
| first_indexed | 2024-12-22T09:28:40Z |
| format | Article |
| id | doaj.art-b658311bec9d4b28a157656f2d6a6d6b |
| institution | Directory Open Access Journal |
| issn | 2155-0417 |
| language | English |
| last_indexed | 2024-12-22T09:28:40Z |
| publishDate | 2013-01-01 |
| publisher | University of Minnesota Libraries Publishing |
| record_format | Article |
| series | INNOVATIONS in Pharmacy |
| spelling | doaj.art-b658311bec9d4b28a157656f2d6a6d6b2022-12-21T18:31:00ZengUniversity of Minnesota Libraries PublishingINNOVATIONS in Pharmacy2155-04172013-01-0142112Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision MakingAngela Smith, PharmD CandidateAmy L. Stockert, PhDJeffery N. Talbot, PhD,David F. Kisor, BS, PharmDObjective: To evaluate a pilot of a laboratory model for relating pharmacogenetics to clinical decision making. Case Study: This pilot was undertaken and evaluated to help determine if a pharmacogenetics laboratory should be included in the core Doctor of Pharmacy curriculum. The placement of the laboratory exercise in the curriculum was determined by identifying the point in the curriculum where the students had been introduced to the chemistry of deoxyribonucleic acid (DNA) as well as instructed on the chemistry of genetic variation. The laboratory included cytochrome P450 2C19 genotyping relative to the *2 variant. Twenty-four students served as the pilot group. Students provided buccal swabs as the source of DNA. Students stabilized the samples and were then provided instructions related to sample preparation, polymerase chain reaction, and gel electrophoresis. The results were reported as images of gels. Students used a reference gel image to compare their results to. Students then applied a dosing algorithm to make a “clinical decision” relative to clopidogrel use. Students were offered a post laboratory survey regarding attitudes toward the laboratory. Twenty-four students completed the laboratory with genotyping results being provided for 22 students (91.7%). Sixteen students were wild-type (*1/*1), while six students were heterozygous (*1/*2). Twenty-three students (96%) completed the post laboratory survey. All 23 agreed (6, 26.1%) or strongly agreed (17, 73.9%) that the laboratory “had relevance and value in the pharmacy curriculum”. Conclusion: The post pilot study survey exploring a laboratory model for pharmacogenetics related to clinical decision making indicated that such a laboratory would be viewed positively by students. This model may be adopted by colleges to expand pharmacogenetics education.http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_445106.pdfpharmacogenetics educationpharmacogenomics educationpharmacogenetics laboratory modelclinical decision making laboratory |
| spellingShingle | Angela Smith, PharmD Candidate Amy L. Stockert, PhD Jeffery N. Talbot, PhD, David F. Kisor, BS, PharmD Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making INNOVATIONS in Pharmacy pharmacogenetics education pharmacogenomics education pharmacogenetics laboratory model clinical decision making laboratory |
| title | Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making |
| title_full | Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making |
| title_fullStr | Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making |
| title_full_unstemmed | Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making |
| title_short | Exploring a Laboratory Model of Pharmacogenetics as Applied to Clinical Decision Making |
| title_sort | exploring a laboratory model of pharmacogenetics as applied to clinical decision making |
| topic | pharmacogenetics education pharmacogenomics education pharmacogenetics laboratory model clinical decision making laboratory |
| url | http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_445106.pdf |
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