Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential

Interleukin-21 Influences Glioblastoma Course: Biological Mechanisms and Therapeutic Potential

Brain tumors represent a heterogeneous group of neoplasms involving the brain or nearby tissues, affecting populations of all ages with a high incidence worldwide. Among the primary brain tumors, the most aggressive and also the most common is glioblastoma (GB), a type of glioma that falls into the...

Full description

Bibliographic Details
Main Authors:	Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	Cells
Subjects:	primary brain tumors glioblastoma interleukin-21 cytokines cancer immunology
Online Access:	https://www.mdpi.com/2073-4409/12/18/2284

Similar Items

TAK1 Inhibitor Enhances the Therapeutic Treatment for Glioblastoma
by: Michela Campolo, et al.
Published: (2020-12-01)

Signaling Pathways of AXL Receptor Tyrosine Kinase Contribute to the Pathogenetic Mechanisms of Glioblastoma
by: Alberto Repici, et al.
Published: (2024-02-01)

Role of Fibroblast Growth Factors Receptors (FGFRs) in Brain Tumors, Focus on Astrocytoma and Glioblastoma
by: Alessio Ardizzone, et al.
Published: (2020-12-01)

Adenosine Targeting as a New Strategy to Decrease Glioblastoma Aggressiveness
by: Valentina Bova, et al.
Published: (2022-08-01)

The Effect of Crosin on Expression of Interleukin 6 in Human Glioblastoma Cell Line
by: Nooshin Delfan, et al.
Published: (2019-10-01)

Upregulation of Interleukin 21 and Interleukin 21 Receptor in Patients with Dermatomyositis and Polymyositis
by: Tao Liu, et al.
Published: (2017-01-01)

KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation
by: Sarah Adriana Scuderi, et al.
Published: (2021-07-01)

Interleukin-11/IL-11 Receptor Promotes Glioblastoma Cell Proliferation, Epithelial–Mesenchymal Transition, and Invasion
by: Sarah F. Stuart, et al.
Published: (2024-01-01)

Sodium Propionate Contributes to Tumor Cell Growth Inhibition through PPAR-γ Signaling
by: Alessia Filippone, et al.
Published: (2022-12-01)

GSK343, an Inhibitor of Enhancer of Zeste Homolog 2, Reduces Glioblastoma Progression through Inflammatory Process Modulation: Focus on Canonical and Non-Canonical NF-κB/IκBα Pathways
by: Sarah Adriana Scuderi, et al.
Published: (2022-11-01)

The Effect of 3-O-Acetyl-Beta-Boswellic Acid on Interleukin-6 Gene Expression in the Human Glioblastoma Cell Line
by: Atousa Hafizi, et al.
Published: (2019-04-01)

Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value
by: Alessio Ardizzone, et al.
Published: (2023-03-01)

Potential Therapeutic Effects of PPAR Ligands in Glioblastoma
by: Rossella Basilotta, et al.
Published: (2022-02-01)

Role of miRNA-19a in Cancer Diagnosis and Poor Prognosis
by: Alessio Ardizzone, et al.
Published: (2021-04-01)

New Insights into the Mechanism of <i>Ulva pertusa</i> on Colitis in Mice: Modulation of the Pain and Immune System
by: Alessio Ardizzone, et al.
Published: (2023-05-01)

Decreased Serum Levels of Interleukin-4 and Interleukin-21 in New Pemphigus Vulgaris Patients, but Not Chronic Patients With Inactive Disease Compared to Healthy Controls
by: Pegah Shahbazian, et al.
Published: (2021-04-01)

Inhibition of Prolyl Oligopeptidase Prevents Consequences of Reperfusion following Intestinal Ischemia
by: Alessia Filippone, et al.
Published: (2021-09-01)

Interleukin types and its application
by: Jacqueline Arokiaraj, et al.
Published: (2020-01-01)

bFGF-like Activity Supported Tissue Regeneration, Modulated Neuroinflammation, and Rebalanced Ca<sup>2+</sup> Homeostasis following Spinal Cord Injury
by: Alessio Ardizzone, et al.
Published: (2023-09-01)

PEA-OXA Mitigates Oxaliplatin-Induced Painful Neuropathy through NF-κB/Nrf-2 Axis
by: Michela Campolo, et al.
Published: (2021-04-01)

Role of Calixarene in Chemotherapy Delivery Strategies
by: Rossella Basilotta, et al.
Published: (2021-06-01)

Effect of Melatonin on Psoriatic Phenotype in Human Reconstructed Skin Model
by: Sarah Adriana Scuderi, et al.
Published: (2022-03-01)

A Combination of Xyloglucan, Pea Protein and Chia Seed Ameliorates Intestinal Barrier Integrity and Mucosa Functionality in a Rat Model of Constipation-Predominant Irritable Bowel Syndrome
by: Alessia Filippone, et al.
Published: (2022-11-01)

Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children
by: Rachel Engelberg, et al.
Published: (2017-04-01)

Protein Kinase Inhibitors as a New Target for Immune System Modulation and Brain Cancer Management
by: Alessia Filippone, et al.
Published: (2022-12-01)

Interleukin-6-controlled, mesenchymal stem cell-based sodium/iodide symporter gene therapy improves survival of glioblastoma-bearing mice
by: Carolin Kitzberger, et al.
Published: (2023-09-01)

Effect of a Product Containing Xyloglucan and Pea Protein on a Murine Model of Atopic Dermatitis
by: Michela Campolo, et al.
Published: (2020-05-01)

Silencing NUDT21 Attenuates the Mesenchymal Identity of Glioblastoma Cells via the NF-κB Pathway
by: Jia-Cheng Lou, et al.
Published: (2017-12-01)

Correction: Casili et al. Therapeutic Potential of BAY-117082, a Selective NLRP3 Inflammasome Inhibitor, on Metastatic Evolution in Human Oral Squamous Cell Carcinoma (OSCC). <i>Cancers</i> 2023, <i>15</i>, 2796
by: Giovanna Casili, et al.
Published: (2024-03-01)

Therapeutic Potential of BAY-117082, a Selective NLRP3 Inflammasome Inhibitor, on Metastatic Evolution in Human Oral Squamous Cell Carcinoma (OSCC)
by: Giovanna Casili, et al.
Published: (2023-05-01)

Roles of interleukins (interleukin-18 and interleukin-17a) and transforming growth factor-beta markers in the pathogenesis of diabetic kidney diseases
by: Maysam Adnan Mezher, et al.
Published: (2023-01-01)

Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases
by: Shahram Solaymani-Mohammadi, et al.
Published: (2019-12-01)

Topical Delivery of Curcumin by Choline-Calix[4]arene-Based Nanohydrogel Improves Its Therapeutic Effect on a Psoriasis Mouse Model
by: Alessia Filippone, et al.
Published: (2020-07-01)

DKK3 Expression in Glioblastoma: Correlations with Biomolecular Markers
by: Maria Caffo, et al.
Published: (2024-04-01)

Influence of GO-Antisense miRNA-21 on the Expression of Selected Cytokines at Glioblastoma Cell Lines
by: Kutwin M, et al.
Published: (2023-08-01)

LRRK2 Inhibition by PF06447475 Antagonist Modulates Early Neuronal Damage after Spinal Cord Trauma
by: Alessia Filippone, et al.
Published: (2022-08-01)

A new insight into the role of aryl hydrocarbon receptor (AhR) in the migration of glioblastoma by AhR-IL24 axis regulation
by: Yiyun Liu, et al.
Published: (2021-09-01)

Interleukin-6 in Hepatocellular Carcinoma: A Dualistic Point of View
by: Iuliana Nenu, et al.
Published: (2023-09-01)

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases
by: Chin Wai Hui, et al.
Published: (2022-07-01)

Potential Therapeutic Effects of Exosomes Packed With a miR-21-Sponge Construct in a Rat Model of Glioblastoma
by: Hamideh Monfared, et al.
Published: (2019-08-01)