Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease
Periodontal disease is a chronic inflammatory condition affecting about 20–50% of people, worldwide, and manifesting clinically through the detection of gingival inflammation, clinical attachment loss, radiographically assessed resorption of alveolar bone, gingival bleeding upon probing, teeth mobil...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13419 |
| _version_ | 1797467939924869120 |
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| author | Mariacristina Amato Simona Santonocito Gaia Viglianisi Marco Tatullo Gaetano Isola |
| author_facet | Mariacristina Amato Simona Santonocito Gaia Viglianisi Marco Tatullo Gaetano Isola |
| author_sort | Mariacristina Amato |
| collection | DOAJ |
| description | Periodontal disease is a chronic inflammatory condition affecting about 20–50% of people, worldwide, and manifesting clinically through the detection of gingival inflammation, clinical attachment loss, radiographically assessed resorption of alveolar bone, gingival bleeding upon probing, teeth mobility and their potential loss at advanced stages. It is characterized by a multifactorial etiology, including an imbalance of the oral microbiota, mechanical stress and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include eliminating the microbial pathogens and applying biomaterials to treat the bone defects. However, periodontal tissue regeneration via a process consistent with the natural tissue formation process has not yet been achieved. Developmental biology studies state that periodontal tissue is composed of neural crest-derived ectomesenchyme. The aim of this review is to discuss the clinical utility of stem cells in periodontal regeneration by reviewing the relevant literature that assesses the periodontal-regenerative potential of stem cells. |
| first_indexed | 2024-03-09T18:59:54Z |
| format | Article |
| id | doaj.art-b65b660d600e495bb66b893040212478 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:59:54Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b65b660d600e495bb66b8930402124782023-11-24T05:07:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211341910.3390/ijms232113419Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal DiseaseMariacristina Amato0Simona Santonocito1Gaia Viglianisi2Marco Tatullo3Gaetano Isola4Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, 70122 Bari, ItalyDepartment of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, 95124 Catania, ItalyPeriodontal disease is a chronic inflammatory condition affecting about 20–50% of people, worldwide, and manifesting clinically through the detection of gingival inflammation, clinical attachment loss, radiographically assessed resorption of alveolar bone, gingival bleeding upon probing, teeth mobility and their potential loss at advanced stages. It is characterized by a multifactorial etiology, including an imbalance of the oral microbiota, mechanical stress and systemic diseases such as diabetes mellitus. The current standard treatments for periodontitis include eliminating the microbial pathogens and applying biomaterials to treat the bone defects. However, periodontal tissue regeneration via a process consistent with the natural tissue formation process has not yet been achieved. Developmental biology studies state that periodontal tissue is composed of neural crest-derived ectomesenchyme. The aim of this review is to discuss the clinical utility of stem cells in periodontal regeneration by reviewing the relevant literature that assesses the periodontal-regenerative potential of stem cells.https://www.mdpi.com/1422-0067/23/21/13419periodontitisstem cellsoral mesenchymaltarget therapiesperiodontal regenerationbone healing |
| spellingShingle | Mariacristina Amato Simona Santonocito Gaia Viglianisi Marco Tatullo Gaetano Isola Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease International Journal of Molecular Sciences periodontitis stem cells oral mesenchymal target therapies periodontal regeneration bone healing |
| title | Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease |
| title_full | Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease |
| title_fullStr | Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease |
| title_full_unstemmed | Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease |
| title_short | Impact of Oral Mesenchymal Stem Cells Applications as a Promising Therapeutic Target in the Therapy of Periodontal Disease |
| title_sort | impact of oral mesenchymal stem cells applications as a promising therapeutic target in the therapy of periodontal disease |
| topic | periodontitis stem cells oral mesenchymal target therapies periodontal regeneration bone healing |
| url | https://www.mdpi.com/1422-0067/23/21/13419 |
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