<i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism
Given the association between deviated inflammatory chemokines, the pathogenesis of autism spectrum disorders (ASD), and our previous findings of the <i>Chanwuyi</i> Lifestyle Medicine Program regarding improved cognitive and behavioral problems in ASD, the present study aims to explore...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | NeuroSci |
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| Online Access: | https://www.mdpi.com/2673-4087/2/2/15 |
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| author | Agnes S. Chan Yvonne M. Y. Han Sophia L. Sze Chun-kwok Wong Ida M. T. Chu Mei-chun Cheung |
| author_facet | Agnes S. Chan Yvonne M. Y. Han Sophia L. Sze Chun-kwok Wong Ida M. T. Chu Mei-chun Cheung |
| author_sort | Agnes S. Chan |
| collection | DOAJ |
| description | Given the association between deviated inflammatory chemokines, the pathogenesis of autism spectrum disorders (ASD), and our previous findings of the <i>Chanwuyi</i> Lifestyle Medicine Program regarding improved cognitive and behavioral problems in ASD, the present study aims to explore if this intervention can alter pro-inflammatory chemokines concentration. Thirty-two boys with ASD were assigned to the experimental group receiving the <i>Chanwuyi</i> Lifestyle Medicine Program for 7 months or the control group without a change in their lifestyle. The experimental group, but not the control group, demonstrated significantly reduced CCL2 and CXCL8, a trend of reduction in CCL5, and elevation of CXCL9. The experimental group also demonstrated significantly reduced social communication problems, repetitive/stereotypic behaviors, and hyperactive behaviors. The present findings support the potential efficacy and applicability of the <i>Chanwuyi</i> Lifestyle Medicine Program for reducing both behavioral problems and immunological dysfunction in ASD. Further studies are warranted to verify its treatment effect and its association with brain functions. |
| first_indexed | 2024-03-10T10:39:22Z |
| format | Article |
| id | doaj.art-b65b79ece831428da8d6555b136c6cd8 |
| institution | Directory Open Access Journal |
| issn | 2673-4087 |
| language | English |
| last_indexed | 2024-03-10T10:39:22Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | NeuroSci |
| spelling | doaj.art-b65b79ece831428da8d6555b136c6cd82023-11-21T23:03:40ZengMDPI AGNeuroSci2673-40872021-06-012220722310.3390/neurosci2020015<i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in AutismAgnes S. Chan0Yvonne M. Y. Han1Sophia L. Sze2Chun-kwok Wong3Ida M. T. Chu4Mei-chun Cheung5Neuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, ChinaNeuropsychology Laboratory, Department of Psychology, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Social Work, The Chinese University of Hong Kong, Hong Kong, ChinaGiven the association between deviated inflammatory chemokines, the pathogenesis of autism spectrum disorders (ASD), and our previous findings of the <i>Chanwuyi</i> Lifestyle Medicine Program regarding improved cognitive and behavioral problems in ASD, the present study aims to explore if this intervention can alter pro-inflammatory chemokines concentration. Thirty-two boys with ASD were assigned to the experimental group receiving the <i>Chanwuyi</i> Lifestyle Medicine Program for 7 months or the control group without a change in their lifestyle. The experimental group, but not the control group, demonstrated significantly reduced CCL2 and CXCL8, a trend of reduction in CCL5, and elevation of CXCL9. The experimental group also demonstrated significantly reduced social communication problems, repetitive/stereotypic behaviors, and hyperactive behaviors. The present findings support the potential efficacy and applicability of the <i>Chanwuyi</i> Lifestyle Medicine Program for reducing both behavioral problems and immunological dysfunction in ASD. Further studies are warranted to verify its treatment effect and its association with brain functions.https://www.mdpi.com/2673-4087/2/2/15autism spectrum disordersinterventionchemokinepro-inflammatorybehavioral problems |
| spellingShingle | Agnes S. Chan Yvonne M. Y. Han Sophia L. Sze Chun-kwok Wong Ida M. T. Chu Mei-chun Cheung <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism NeuroSci autism spectrum disorders intervention chemokine pro-inflammatory behavioral problems |
| title | <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism |
| title_full | <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism |
| title_fullStr | <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism |
| title_full_unstemmed | <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism |
| title_short | <i>Chanwuyi</i> Lifestyle Medicine Program Alleviates Immunological Deviation and Improves Behaviors in Autism |
| title_sort | i chanwuyi i lifestyle medicine program alleviates immunological deviation and improves behaviors in autism |
| topic | autism spectrum disorders intervention chemokine pro-inflammatory behavioral problems |
| url | https://www.mdpi.com/2673-4087/2/2/15 |
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