Teratogenic effects of carbamazepine in mice
Objectives: The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. Materials and Methods: Mature female and male BALB/c mice (25–30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated gro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2017;volume=20;issue=2;spage=132;epage=137;aulast=Jose |
| _version_ | 1818064377466585088 |
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| author | Manna Jose Harikrishnan Vijayakumar Sreelatha Manjula Valiyamattathil James Sabareeswaran Arumughan Sanjeev Varghese Thomas |
| author_facet | Manna Jose Harikrishnan Vijayakumar Sreelatha Manjula Valiyamattathil James Sabareeswaran Arumughan Sanjeev Varghese Thomas |
| author_sort | Manna Jose |
| collection | DOAJ |
| description | Objectives: The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. Materials and Methods: Mature female and male BALB/c mice (25–30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated groups (CBZ 450 mg/kg and 600 mg/kg) were fed on medicinal diet. The dams in the control group were mated on the same day as that of the CBZ-treated dams. After cesarean section (CS), fetal viability status and weights were recorded. Gross histopathological examination of fetuses was conducted to identify alterations in morphology and external or internal organs due to in utero exposure of CBZ. Results: Out of the nine female animals (three treated on CBZ 450 mg/kg, three treated on CBZ 600 mg/kg and three controls), seven were pregnant, and two (one each from the two CBZ-treated groups) were nonpregnant. All fetuses of the control group (n = 31) and CBZ 450 mg/kg treated group (n = 24) were live, but eight out of the twenty fetuses (40%) of CBZ 600 mg/kg treated group were dead at CS. The birth weight of the fetuses antenatally exposed to CBZ was drastically reduced (0.71 ± 0.06) when compared to control fetuses (1.67 ± 0.12) (P < 0.0001). All the fetuses of the CBZ-treated groups showed stunted physical development. Conclusion: Although oral administration of CBZ to mice is a convenient model to study the effect of CBZ to pregnancy, higher oral dose was associated with increased fetal loss. Some of the fetuses exposed to CBZ demonstrated structural abnormalities and low body weight. |
| first_indexed | 2024-12-10T14:35:02Z |
| format | Article |
| id | doaj.art-b65bc3644ed442f5ae697e42d857974d |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-10T14:35:02Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-b65bc3644ed442f5ae697e42d857974d2022-12-22T01:44:52ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492017-01-0120213213710.4103/aian.AIAN_492_16Teratogenic effects of carbamazepine in miceManna JoseHarikrishnan Vijayakumar SreelathaManjula Valiyamattathil JamesSabareeswaran ArumughanSanjeev Varghese ThomasObjectives: The aim of this study was to determine the teratogenic effects of carbamazepine (CBZ) in BALB/c mice. Materials and Methods: Mature female and male BALB/c mice (25–30 g) were used for all experiments. After standardization of administration and dose of CBZ, animals in the CBZ-treated groups (CBZ 450 mg/kg and 600 mg/kg) were fed on medicinal diet. The dams in the control group were mated on the same day as that of the CBZ-treated dams. After cesarean section (CS), fetal viability status and weights were recorded. Gross histopathological examination of fetuses was conducted to identify alterations in morphology and external or internal organs due to in utero exposure of CBZ. Results: Out of the nine female animals (three treated on CBZ 450 mg/kg, three treated on CBZ 600 mg/kg and three controls), seven were pregnant, and two (one each from the two CBZ-treated groups) were nonpregnant. All fetuses of the control group (n = 31) and CBZ 450 mg/kg treated group (n = 24) were live, but eight out of the twenty fetuses (40%) of CBZ 600 mg/kg treated group were dead at CS. The birth weight of the fetuses antenatally exposed to CBZ was drastically reduced (0.71 ± 0.06) when compared to control fetuses (1.67 ± 0.12) (P < 0.0001). All the fetuses of the CBZ-treated groups showed stunted physical development. Conclusion: Although oral administration of CBZ to mice is a convenient model to study the effect of CBZ to pregnancy, higher oral dose was associated with increased fetal loss. Some of the fetuses exposed to CBZ demonstrated structural abnormalities and low body weight.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2017;volume=20;issue=2;spage=132;epage=137;aulast=JoseAntenatal exposurecarbamazepinemouseteratogenicity |
| spellingShingle | Manna Jose Harikrishnan Vijayakumar Sreelatha Manjula Valiyamattathil James Sabareeswaran Arumughan Sanjeev Varghese Thomas Teratogenic effects of carbamazepine in mice Annals of Indian Academy of Neurology Antenatal exposure carbamazepine mouse teratogenicity |
| title | Teratogenic effects of carbamazepine in mice |
| title_full | Teratogenic effects of carbamazepine in mice |
| title_fullStr | Teratogenic effects of carbamazepine in mice |
| title_full_unstemmed | Teratogenic effects of carbamazepine in mice |
| title_short | Teratogenic effects of carbamazepine in mice |
| title_sort | teratogenic effects of carbamazepine in mice |
| topic | Antenatal exposure carbamazepine mouse teratogenicity |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2017;volume=20;issue=2;spage=132;epage=137;aulast=Jose |
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